The renin-angiotensin system has powerful effects in control of the blood pressure and
sodium homeostasis. These actions are coordinated through integrated actions in the …

Intrarenal autoregulatory mechanisms maintain renal blood flow (RBF) and glomerular
filtration rate (GFR) independent of renal perfusion pressure (RPP) over a defined range (80 …

Inappropriate activation of the renin-angiotensin system, which plays a central role in the
regulation of blood pressure, electrolyte, and volume homeostasis, may represent a major …

In this review we outline the unique effects of the autacoid adenosine in the kidney.
Adenosine is present in the cytosol of renal cells and in the extracellular space of normoxic …

There has been an explosive growth of interest in the multiple interacting paracrine systems
that influence renal microvascular function. This review first discusses the membrane …

The protease renin is the key enzyme of the renin-angiotensin-aldosterone cascade, which
is relevant under both physiological and pathophysiological settings. The kidney is the only …

Tubular-fluid reabsorption by specialized cells of the nephron at the junction of the
ascending limb of the loop of Henle and the distal convoluted tubule, termed the macula …

Combined cardiac and renal dysfunction has gained considerable attention. Hypotheses
about its pathogenesis have been formulated, albeit based on a relatively small body of …

Long overlooked as the virtual compartment and then strictly characterized through
descriptive morphologic analysis, the renal interstitium has finally been associated with …

In this review, we will cover (i) the proteolytic cascade of the RAAS,(ii) its regulation by
multiple feedback-controlled parameters, and (iii) the major effects of the RAAS. For the …