Current challenges and best-practice protocols for microbiome analysis

R Bharti, DG Grimm - Briefings in bioinformatics, 2021 - academic.oup.com
Analyzing the microbiome of diverse species and environments using next-generation
sequencing techniques has significantly enhanced our understanding on metabolic …

Metagenomics: An effective approach for exploring microbial diversity and functions

NN Nam, HDK Do, KT Loan Trinh, NY Lee - Foods, 2023 - mdpi.com
Various fields have been identified in the “omics” era, such as genomics, proteomics,
transcriptomics, metabolomics, phenomics, and metagenomics. Among these …

[HTML][HTML] Evidence of escape of SARS-CoV-2 variant B. 1.351 from natural and vaccine-induced sera

D Zhou, W Dejnirattisai, P Supasa, C Liu, AJ Mentzer… - Cell, 2021 - cell.com
The race to produce vaccines against severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) began when the first sequence was published, and this forms the basis for …

[HTML][HTML] Antibody evasion by the P. 1 strain of SARS-CoV-2

W Dejnirattisai, D Zhou, P Supasa, C Liu, AJ Mentzer… - Cell, 2021 - cell.com
Terminating the SARS-CoV-2 pandemic relies upon pan-global vaccination. Current
vaccines elicit neutralizing antibody responses to the virus spike derived from early isolates …

Expanding known viral diversity in the healthy infant gut

SA Shah, L Deng, J Thorsen, AG Pedersen… - Nature …, 2023 - nature.com
The gut microbiome is shaped through infancy and impacts the maturation of the immune
system, thus protecting against chronic disease later in life. Phages, or viruses that infect …

[HTML][HTML] Multiple wheat genomes reveal global variation in modern breeding

S Walkowiak, L Gao, C Monat, G Haberer, MT Kassa… - Nature, 2020 - nature.com
Advances in genomics have expedited the improvement of several agriculturally important
crops but similar efforts in wheat (Triticum spp.) have been more challenging. This is largely …

A genomic catalog of Earth's microbiomes

S Nayfach, S Roux, R Seshadri, D Udwary… - Nature …, 2021 - nature.com
The reconstruction of bacterial and archaeal genomes from shotgun metagenomes has
enabled insights into the ecology and evolution of environmental and host-associated …

COG database update: focus on microbial diversity, model organisms, and widespread pathogens

MY Galperin, YI Wolf, KS Makarova… - Nucleic acids …, 2021 - academic.oup.com
Abstract The Clusters of Orthologous Genes (COG) database, also referred to as the
Clusters of Orthologous Groups of proteins, was created in 1997 and went through several …

eggNOG-mapper v2: functional annotation, orthology assignments, and domain prediction at the metagenomic scale

CP Cantalapiedra, A Hernández-Plaza… - Molecular biology …, 2021 - academic.oup.com
Even though automated functional annotation of genes represents a fundamental step in
most genomic and metagenomic workflows, it remains challenging at large scales. Here, we …

Forecasting the dissemination of antibiotic resistance genes across bacterial genomes

MMH Ellabaan, C Munck, A Porse, L Imamovic… - Nature …, 2021 - nature.com
Antibiotic resistance spreads among bacteria through horizontal transfer of antibiotic
resistance genes (ARGs). Here, we set out to determine predictive features of ARG transfer …