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Current challenges and best-practice protocols for microbiome analysis
Analyzing the microbiome of diverse species and environments using next-generation
sequencing techniques has significantly enhanced our understanding on metabolic …
sequencing techniques has significantly enhanced our understanding on metabolic …
Metagenomics: An effective approach for exploring microbial diversity and functions
Various fields have been identified in the “omics” era, such as genomics, proteomics,
transcriptomics, metabolomics, phenomics, and metagenomics. Among these …
transcriptomics, metabolomics, phenomics, and metagenomics. Among these …
[HTML][HTML] Evidence of escape of SARS-CoV-2 variant B. 1.351 from natural and vaccine-induced sera
The race to produce vaccines against severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) began when the first sequence was published, and this forms the basis for …
(SARS-CoV-2) began when the first sequence was published, and this forms the basis for …
[HTML][HTML] Antibody evasion by the P. 1 strain of SARS-CoV-2
Terminating the SARS-CoV-2 pandemic relies upon pan-global vaccination. Current
vaccines elicit neutralizing antibody responses to the virus spike derived from early isolates …
vaccines elicit neutralizing antibody responses to the virus spike derived from early isolates …
Expanding known viral diversity in the healthy infant gut
The gut microbiome is shaped through infancy and impacts the maturation of the immune
system, thus protecting against chronic disease later in life. Phages, or viruses that infect …
system, thus protecting against chronic disease later in life. Phages, or viruses that infect …
[HTML][HTML] Multiple wheat genomes reveal global variation in modern breeding
Advances in genomics have expedited the improvement of several agriculturally important
crops but similar efforts in wheat (Triticum spp.) have been more challenging. This is largely …
crops but similar efforts in wheat (Triticum spp.) have been more challenging. This is largely …
A genomic catalog of Earth's microbiomes
The reconstruction of bacterial and archaeal genomes from shotgun metagenomes has
enabled insights into the ecology and evolution of environmental and host-associated …
enabled insights into the ecology and evolution of environmental and host-associated …
COG database update: focus on microbial diversity, model organisms, and widespread pathogens
Abstract The Clusters of Orthologous Genes (COG) database, also referred to as the
Clusters of Orthologous Groups of proteins, was created in 1997 and went through several …
Clusters of Orthologous Groups of proteins, was created in 1997 and went through several …
eggNOG-mapper v2: functional annotation, orthology assignments, and domain prediction at the metagenomic scale
Even though automated functional annotation of genes represents a fundamental step in
most genomic and metagenomic workflows, it remains challenging at large scales. Here, we …
most genomic and metagenomic workflows, it remains challenging at large scales. Here, we …
Forecasting the dissemination of antibiotic resistance genes across bacterial genomes
Antibiotic resistance spreads among bacteria through horizontal transfer of antibiotic
resistance genes (ARGs). Here, we set out to determine predictive features of ARG transfer …
resistance genes (ARGs). Here, we set out to determine predictive features of ARG transfer …