[HTML][HTML] Cytotoxic urea Schiff base complexes for multidrug discovery as anticancer activity and low in vivo oral assessing toxicity

LM Aroua, AN Al-Hakimi, MAM Abdulghani… - Arabian Journal of …, 2022 - Elsevier
Novel mononuclear complexes 2–8 derived from hybrid Urea Schiff base HL were
synthesized using various metal Ni 2+, Fe 3+, Cu 2+, Co 2+, Mn 2+, Zn 2+, and Cr 3+. The …

Silver nanoparticle functionalized by glutamine and conjugated with thiosemicarbazide induces apoptosis in colon cancer cell line

H Taati, H Sangani, A Davoudi… - Scientific Reports, 2024 - nature.com
The high mortality rate of colon cancer indicates the insufficient efficacy of current
chemotherapy. Thus, the discussion on engineered metal nanoparticles in the treatment of …

Design, synthesis, cytotoxic screening and molecular docking studies of novel hybrid thiosemicarbazone derivatives as anticancer agents

FZ Mohammed, YW Rizzk, IM El Deen… - Chemistry & …, 2021 - Wiley Online Library
Thiosemicarbazones have been the focus of scientists owing to their broad clinical
anticancer range. Herein, A Series of new thiosemicarbazone derivatives 5–9 were …

[HTML][HTML] Oxamic acid thiohydrazides and hydrazones based on them as convenient starting compounds for the synthesis of S-and N-containing heterocyclic products …

MM Krayushkin, VN Yarovenko - Arabian Journal of Chemistry, 2024 - Elsevier
The chemistry of hydrazones is currently undergoing intensive development. For example,
thioacylhydrazones, which are synthesized most often from thiosemicarbazides, have …

Versatile Biological Activities of Thiosemicarbazones and Their Metal Complexes

SB Zahra, A Khan, N Ahmed, M Rafique… - Journal of Molecular …, 2024 - Elsevier
One of the most crucial objectives in medicinal chemistry is the development of innovative
and beneficial bioactive compounds with various biological activities. Thiosemicarbazone …

Structural elucidation, Hirshfeld surface, DFT, molecular docking and molecular dynamics studies of a novel thiazole derivative as anti-cancer drug

S Neetha, C Santhosh, K Sharath, M Sridhar - Journal of Molecular …, 2025 - Elsevier
Detailed structural and non-covalent interactions in the novel thiazole derivative benzyl 4-(4-
chlorophenyl) thiazole-2-carboxylate (6a) has been synthesized and characterized by …

New 1, 3, 4-thiadiazoles derivatives: Synthesis, antiproliferative activity, molecular docking and molecular dynamics

A Bimoussa, A Oubella, FZ Bamou… - Future Medicinal …, 2022 - Taylor & Francis
Aim: A series of 1, 3, 4-thiadiazole himachalene hybrids were prepared from the treatment of
a himachalen-4-one thiosemicarbazone derivative with N-aryl-C-ethoxycarbonyl-nitrilimines …

Anticancer Studies of Newly Synthesized Thiazole Derivatives: Synthesis, Characterization, Biological Activity, and Molecular Docking

FA Al-Salmi, AH Alrohaimi, ME Behery, W Megahed… - Crystals, 2023 - mdpi.com
Thiazole and its derivatives have received a lot of attention from researchers due to its wide
biological, pharmacological, and anticancer properties. A novel series of 2-[2-[4-Hydroxy-3 …

Cytotoxicity effect of nickel hydroxide nanoparticles functionalized by glutamine and conjugated by thiosemicarbazide on human lung cancer cell line (A549) and …

AA Dehkaei, K Khalatbari, A Emamifar, SM Taramsari… - Gene Reports, 2022 - Elsevier
Lung cancer is the second leading cause of cancer-associated death, worldwide and current
therapeutic approaches have low efficiency in treating metastatic lung cancers …

Dual PI3K/Akt inhibitors bearing coumarin-thiazolidine pharmacophores as potential apoptosis inducers in MCF-7 cells

RM Abdelnaby, HS Rateb, O Ali, AS Saad, RI Nadeem… - Pharmaceuticals, 2022 - mdpi.com
Breast cancer is the most common malignancy worldwide; therefore, the development of
new anticancer agents is essential for improved tumor control. By adopting the …