The contribution of glutamate to synaptic transmission, plasticity and development is well
established; current evidence is based on diverse approaches to decipher function and …

In order to guarantee better conditions for competition, the nervous system has developed
not only mechanisms controlling muscle effectors, but also retrograde systems that, starting …

This study was designed to identify molecular mechanisms by which exercise affects
synaptic-plasticity in the hippocampus, a brain area whose function, learning and memory …

Exercise, a behavior that is inherently associated with energy metabolism, impacts the
molecular systems important for synaptic plasticity and learning and memory. This implies …

The effects of lead (Pb2+) on human health have been recognized since antiquity. However,
it was not until the 1970s that seminal epidemiological studies provided evidence on the …

As a major metabolite of kynurenine in the oxidative metabolism of tryptophan, kynurenic
acid is of considerable biological and clinical importance as an endogenous antagonist of …

NMDA ionotropic glutamate receptors (NMDARs) are crucial in activity‐dependent synaptic
changes and in learning and memory. NMDARs are composed of two GluN1 essential …

Long-term memory (LTM) consolidation requires the synthesis of plasticity-related proteins
(PRPs). In addition, we have shown recently that LTM formation also requires the setting of a …

Similar molecular machinery is activated in neurons following an electrical stimulus that
induces synaptic changes and after learning sessions that trigger memory formation. Then …

Long‐term deficits in cognitive function are the principal effects of lead (Pb2+) exposure in
children and can be modeled in experimental animals. Current therapeutic approaches in …