The exposome: molecules to populations
Derived from the term exposure, the exposome is an omic-scale characterization of the
nongenetic drivers of health and disease. With the genome, it defines the phenome of an …
nongenetic drivers of health and disease. With the genome, it defines the phenome of an …
The placental epigenome as a molecular link between prenatal exposures and fetal health outcomes through the DOHaD hypothesis
Abstract Purpose of Review The developmental origins of health and disease (DOHaD)
hypothesis posits that the perinatal environment can impact fetal and later life health. The …
hypothesis posits that the perinatal environment can impact fetal and later life health. The …
Cadmium: Toxic effects on placental and embryonic development
HX Geng, L Wang - Environmental toxicology and pharmacology, 2019 - Elsevier
Cadmium is a non-essential trace metal that has strong teratogenic and mutagenic effects in
living organisms. The content is more highly enriched in women than in men and can enter …
living organisms. The content is more highly enriched in women than in men and can enter …
Multi-omics signatures of the human early life exposome
Environmental exposures during early life play a critical role in life-course health, yet the
molecular phenotypes underlying environmental effects on health are poorly understood. In …
molecular phenotypes underlying environmental effects on health are poorly understood. In …
[HTML][HTML] Environmental cadmium exposure induces fetal growth restriction via triggering PERK-regulated mitophagy in placental trophoblasts
HL Zhu, XT Shi, XF Xu, YW **ong, SJ Yi, GX Zhou… - Environment …, 2021 - Elsevier
Cadmium (Cd), an environmental toxicant, is positively associated with fetal growth
restriction (FGR). However, the mechanism by which gestational exposure to Cd induces …
restriction (FGR). However, the mechanism by which gestational exposure to Cd induces …
Exposure to cadmium induces neuroinflammation and impairs ciliogenesis in hESC-derived 3D cerebral organoids
Y Huang, Y Dai, M Li, L Guo, C Cao, Y Huang… - Science of The Total …, 2021 - Elsevier
Cadmium (Cd) is an environmental heavy metal toxicant with central nervous system toxicity
and has a greater negative impact on fetal neurodevelopment. However, the causative …
and has a greater negative impact on fetal neurodevelopment. However, the causative …
Placental genomics mediates genetic associations with complex health traits and disease
As the master regulator in utero, the placenta is core to the Developmental Origins of Health
and Disease (DOHaD) hypothesis but is historically understudied. To identify placental gene …
and Disease (DOHaD) hypothesis but is historically understudied. To identify placental gene …
Praegnatio perturbatio—impact of endocrine-disrupting chemicals
V Padmanabhan, W Song… - Endocrine …, 2021 - academic.oup.com
The burden of adverse pregnancy outcomes such as preterm birth and low birth weight is
considerable across the world. Several risk factors for adverse pregnancy outcomes have …
considerable across the world. Several risk factors for adverse pregnancy outcomes have …
A machine learning approach to brain epigenetic analysis reveals kinases associated with Alzheimer's disease
Alzheimer's disease (AD) is influenced by both genetic and environmental factors; thus,
brain epigenomic alterations may provide insights into AD pathogenesis. Multiple array …
brain epigenomic alterations may provide insights into AD pathogenesis. Multiple array …
Prenatal air pollution exposure and placental DNA methylation changes: implications on fetal development and future disease susceptibility
The Developmental Origins of Health and Disease (DOHaD) concept postulates that in utero
exposures influence fetal programming and health in later life. Throughout pregnancy, the …
exposures influence fetal programming and health in later life. Throughout pregnancy, the …