Molecular and cellular mechanisms that regulate human erythropoiesis
To enable effective oxygen transport,∼ 200 billion red blood cells (RBCs) need to be
produced every day in the bone marrow through the fine-tuned process of erythropoiesis …
produced every day in the bone marrow through the fine-tuned process of erythropoiesis …
Basic methods of cell cycle analysis
A Ligasová, I Frydrych, K Koberna - International Journal of Molecular …, 2023 - mdpi.com
Cellular growth and the preparation of cells for division between two successive cell
divisions is called the cell cycle. The cell cycle is divided into several phases; the length of …
divisions is called the cell cycle. The cell cycle is divided into several phases; the length of …
Population snapshots predict early haematopoietic and erythroid hierarchies
The formation of red blood cells begins with the differentiation of multipotent haematopoietic
progenitors. Reconstructing the steps of this differentiation represents a general challenge in …
progenitors. Reconstructing the steps of this differentiation represents a general challenge in …
Planarian stem cells specify fate yet retain potency during the cell cycle
Planarian whole-body regeneration is enabled by stem cells called neoblasts. At least some
neoblasts are individually pluripotent. Neoblasts are also heterogeneous, with …
neoblasts are individually pluripotent. Neoblasts are also heterogeneous, with …
The molecular signature of megakaryocyte-erythroid progenitors reveals a role for the cell cycle in fate specification
YC Lu, C Sanada, J Xavier-Ferrucio, L Wang… - Cell reports, 2018 - cell.com
Megakaryocytic-erythroid progenitors (MEPs) give rise to the cells that produce red blood
cells and platelets. Although the mechanisms underlying megakaryocytic (MK) and erythroid …
cells and platelets. Although the mechanisms underlying megakaryocytic (MK) and erythroid …
EpoR stimulates rapid cycling and larger red cells during mouse and human erythropoiesis
The erythroid terminal differentiation program couples sequential cell divisions with
progressive reductions in cell size. The erythropoietin receptor (EpoR) is essential for …
progressive reductions in cell size. The erythropoietin receptor (EpoR) is essential for …
RNA polymerase II pausing temporally coordinates cell cycle progression and erythroid differentiation
Controlled release of promoter-proximal paused RNA polymerase II (RNA Pol II) is crucial
for gene regulation. However, studying RNA Pol II pausing is challenging, as pause-release …
for gene regulation. However, studying RNA Pol II pausing is challenging, as pause-release …
Decoding the pathogenesis of Diamond–Blackfan anemia using single-cell RNA-seq
B Wang, C Wang, Y Wan, J Gao, Y Ma, Y Zhang… - Cell Discovery, 2022 - nature.com
Ribosomal protein dysfunction causes diverse human diseases, including Diamond–
Blackfan anemia (DBA). Despite the universal need for ribosomes in all cell types, the …
Blackfan anemia (DBA). Despite the universal need for ribosomes in all cell types, the …
Linking cell cycle to hematopoietic stem cell fate decisions
S Treichel, MD Filippi - Frontiers in Cell and Developmental Biology, 2023 - frontiersin.org
Hematopoietic stem cells (HSCs) have the properties to self-renew and/or differentiate into
any blood cell lineages. In order to balance the maintenance of the stem cell pool with …
any blood cell lineages. In order to balance the maintenance of the stem cell pool with …
FBXO11-mediated proteolysis of BAHD1 relieves PRC2-dependent transcriptional repression in erythropoiesis
The histone mark H3K27me3 and its reader/writer polycomb repressive complex 2 (PRC2)
mediate widespread transcriptional repression in stem and progenitor cells. Mechanisms …
mediate widespread transcriptional repression in stem and progenitor cells. Mechanisms …