Mammalian eggs (oocytes) are formed during fetal life and establish associations with
somatic cells to form primordial follicles that create a store of germ cells (the primordial pool) …

BACKGROUND Regulated cell death is a fundamental component of numerous
physiological processes; spanning from organogenesis in utero, to normal cell turnover …

Gonadal development is a complex process that involves sex determination followed by
divergent maturation into either testes or ovaries. Historically, limited tissue accessibility, a …

The human ovary orchestrates sex hormone production and undergoes monthly structural
changes to release mature oocytes. The outer lining of the ovary (cortex) has a key role in …

Reproductive ageing in females is defined by a progressive decline in follicle number and
oocyte quality. This is a natural process that leads to the loss of fertility and ovarian function …

In women, the non-growing population of follicles that comprise the ovarian reserve is
determined at birth and serves as the reservoir for future fertility. This reserve of dormant …

Some survivors of childhood, adolescent, and young adult cancer are at increased risk of
gonadal dysfunction and adverse pregnancy outcomes. We reviewed currently available …

BACKGROUND Neurotrophins [nerve growth factor (NGF), brain-derived neurotrophic factor
(BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4)] and glial cell line-derived …

It is well established that DNA-damaging chemotherapies can cause infertility and ovarian
endocrine failure by depleting the ovarian reserve of primordial follicles. Currently, no …

Ovarian aging is a natural process characterized by follicular depletion and a reduction in
oocyte quality, resulting in loss of ovarian function, cycle irregularity and eventually infertility …