The rapid scientific interest in gut microbiota (GM) has coincided with a global increase in
the prevalence of infectious and non-infectivous liver diseases. GM, which is also called “the …

Cirrhosis–the common end-stage of chronic liver disease–is associated with a cascade of
events, of which intestinal bacterial overgrowth and dysbiosis are central. Bacterial toxins …

Highlights•Drivers of low-diversity dysbiosis include antibiotics, host genetics,
physiology.•Dysbiosis results in shifts in microbial composition and function.•Dysbiosis …

The human gut microbiome has emerged as a major player in human health and disease.
The liver, as the first organ to encounter microbial products that cross the gut epithelial …

The gut-liver axis is widely implicated in the pathogenesis of liver diseases, where it is
increasingly the focus of clinical research. Recent studies trialling an array of therapeutic …

The liver carries out a wide range of functions ranging from the control of metabolites,
nutrient storage, and detoxification to immunosurveillance. While inflammation is essential …

Cognitive frailty, defined as the coexistence of mild cognitive impairment symptoms and
physical frailty phenotype in older persons, is increasingly considered the main geriatric …

Cirrhosis is a prevalent cause of morbidity and mortality, especially for those at an advanced
decompensated stage. Cirrhosis development and progression involves several important …

Bifidobacterium is a widely distributed commensal bacterial genus that displays beneficial
pro-homeostatic and anti-inflammatory immunomodulatory properties. Depletion or absence …

Patients with chronic liver disease and cirrhosis demonstrate a global mucosal immune
impairment, which is associated with altered gut microbiota composition and functionality …