A guide to plasma membrane solute carrier proteins
This review aims to serve as an introduction to the solute carrier proteins (SLC) superfamily
of transporter proteins and their roles in human cells. The SLC superfamily currently …
of transporter proteins and their roles in human cells. The SLC superfamily currently …
Emerging diversity in lipid–protein interactions
Membrane lipids interact with proteins in a variety of ways, ranging from providing a stable
membrane environment for proteins to being embedded in to detailed roles in complicated …
membrane environment for proteins to being embedded in to detailed roles in complicated …
Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus
Abstract Background The fungal genus Aspergillus is of critical importance to humankind.
Species include those with industrial applications, important pathogens of humans, animals …
Species include those with industrial applications, important pathogens of humans, animals …
Molecular mechanism of prestin electromotive signal amplification
Hearing involves two fundamental processes: mechano-electrical transduction and signal
amplification. Despite decades of studies, the molecular bases for both remain elusive …
amplification. Despite decades of studies, the molecular bases for both remain elusive …
Dimeric transport mechanism of human vitamin C transporter SVCT1
TA Kobayashi, H Shimada, FK Sano, Y Itoh… - Nature …, 2024 - nature.com
Vitamin C plays important roles as a cofactor in many enzymatic reactions and as an
antioxidant against oxidative stress. As some mammals including humans cannot synthesize …
antioxidant against oxidative stress. As some mammals including humans cannot synthesize …
Cryo-EM structures and functional characterization of murine Slc26a9 reveal mechanism of uncoupled chloride transport
The epithelial anion transporter SLC26A9 contributes to airway surface hydration and
gastric acid production. Colocalizing with CFTR, SLC26A9 has been proposed as a target …
gastric acid production. Colocalizing with CFTR, SLC26A9 has been proposed as a target …
The two-domain elevator-type mechanism of zinc-transporting ZIP proteins
A Wiuf, JH Steffen, ER Becares, C Grønberg… - Science …, 2022 - science.org
Zinc is essential for all organisms and yet detrimental at elevated levels. Hence,
homeostasis of this metal is tightly regulated. The Zrt/Irt-like proteins (ZIPs) represent the …
homeostasis of this metal is tightly regulated. The Zrt/Irt-like proteins (ZIPs) represent the …
Elevator-type mechanisms of membrane transport
AA Garaeva, DJ Slotboom - Biochemical Society Transactions, 2020 - portlandpress.com
Membrane transporters are integral membrane proteins that mediate the passage of solutes
across lipid bilayers. These proteins undergo conformational transitions between outward …
across lipid bilayers. These proteins undergo conformational transitions between outward …
Engineering cellular metabolite transport for biosynthesis of computationally predicted tropane alkaloid derivatives in yeast
Microbial biosynthesis of plant natural products (PNPs) can facilitate access to valuable
medicinal compounds and derivatives. Such efforts are challenged by metabolite transport …
medicinal compounds and derivatives. Such efforts are challenged by metabolite transport …
Structure and function of an Arabidopsis thaliana sulfate transporter
Plant sulfate transporters (SULTR) mediate absorption and distribution of sulfate (SO42−)
and are essential for plant growth; however, our understanding of their structures and …
and are essential for plant growth; however, our understanding of their structures and …