INTRODUCTION Only 2.4% of the 16.5-kb mitochondrial DNA (mtDNA) genome shows
homoplasmic variation at> 1% frequency in humans. Migration patterns have contributed to …

Importance Atrial fibrillation (AF) is the most common arrhythmia affecting 1% of the
population. Young individuals with AF have a strong genetic association with the disease …

The substantial phenotypic heterogeneity in autism limits our understanding of its genetic
etiology. To address this gap, here we investigated genetic differences between autistic …

A family history of atrial fibrillation constitutes a substantial risk of develo** the disease,
however, the pathogenesis of this complex disease is poorly understood. We perform whole …

Introduction Although the relationship between APOE and Alzheimer's disease (AD) is well
established in populations of European descent, the effects of APOE and ancestry on AD …

Background Common bean is an important staple crop in the tropics of Africa, Asia and the
Americas. Particularly smallholder farmers rely on bean as a source for calories, protein and …

Orofacial clefts are common developmental disorders that pose significant clinical,
economical and psychological problems. We conducted genome-wide association analyses …

When testing genotype–phenotype associations using linear regression, departure of the
trait distribution from normality can impact both Type I error rate control and statistical power …

Fusarium wilt, a soil-borne disease caused by the fungal pathogen Fusarium oxysporum f.
sp. fragariae, threatens strawberry (Fragaria× ananassa) production worldwide. The spread …

Organisms living in seasonally variable environments utilize cues such as light and
temperature to induce plastic responses, enabling them to exploit favorable seasons and …