MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial
This multi-site, randomized, double-blind, confirmatory phase 3 study evaluated the efficacy
and safety of 3, 4-methylenedioxymethamphetamine-assisted therapy (MDMA-AT) versus …
and safety of 3, 4-methylenedioxymethamphetamine-assisted therapy (MDMA-AT) versus …
Therapeutic mechanisms of psychedelics and entactogens
Recent clinical and preclinical evidence suggests that psychedelics and entactogens may
produce both rapid and sustained therapeutic effects across several indications. Currently …
produce both rapid and sustained therapeutic effects across several indications. Currently …
[HTML][HTML] Alleviating anxiety and taming trauma: novel pharmacotherapeutics for anxiety disorders and posttraumatic stress disorder
Psychiatric disorders associated with psychological trauma, stress and anxiety are a highly
prevalent and increasing cause of morbidity worldwide. Current therapeutic approaches …
prevalent and increasing cause of morbidity worldwide. Current therapeutic approaches …
[HTML][HTML] MDMA-assisted psychotherapy for PTSD: growing evidence for memory effects mediating treatment efficacy
The application of MDMA in conjunction with psychotherapy has in recent years seen a
resurgence of clinical, scientific, and public interest in the treatment of posttraumatic stress …
resurgence of clinical, scientific, and public interest in the treatment of posttraumatic stress …
Psilocybin facilitates fear extinction: importance of dose, context, and serotonin receptors
SC Woodburn, CM Levitt, AM Koester… - ACS Chemical …, 2024 - ACS Publications
A variety of classic psychedelics and MDMA have been shown to enhance fear extinction in
rodent models. This has translational significance because a standard treatment for post …
rodent models. This has translational significance because a standard treatment for post …
Altered brain activity and functional connectivity after MDMA-assisted therapy for post-traumatic stress disorder
Introduction 3, 4-methylenedioxymethamphetamine-assisted therapy (MDMA-AT) for post-
traumatic stress disorder (PTSD) has demonstrated promise in multiple clinical trials. MDMA …
traumatic stress disorder (PTSD) has demonstrated promise in multiple clinical trials. MDMA …
Methylenedioxymethamphetamine is a connectogen with empathogenic, entactogenic, and still further connective properties: It is time to reconcile “the great …
K Stocker, ME Liechti - Journal of Psychopharmacology, 2024 - journals.sagepub.com
Science on methylenedioxymethamphetamine (MDMA) and MDMA-like substances is faced
with the unique situation that this class of psychoactive agents is referred to with two basic …
with the unique situation that this class of psychoactive agents is referred to with two basic …
MDMA-assisted psychotherapy for PTSD in adolescents: rationale, potential, risks, and considerations
Methylenedioxymetamphetamine (MDMA)-assisted psychotherapy (MDMA-AP) is a
proposed treatment for posttraumatic stress disorder (PTSD) that may be approved for adults …
proposed treatment for posttraumatic stress disorder (PTSD) that may be approved for adults …
Examining the role of oxytocinergic signaling and neuroinflammatory markers in the therapeutic effects of MDMA in a rat model for PTSD
H Avgana, RS Toledano, I Akirav - Pharmaceuticals, 2024 - mdpi.com
MDMA-assisted psychotherapy has shown potential as an effective treatment for post-
traumatic stress disorder (PTSD). Preclinical studies involving rodents have demonstrated …
traumatic stress disorder (PTSD). Preclinical studies involving rodents have demonstrated …
Altered states and social bonds: Effects of MDMA and serotonergic psychedelics on social behavior as a mechanism underlying substance-assisted therapy
Background There has been renewed interest in the use of 3, 4-methylenedioxy-
methamphetamine (MDMA) and serotonergic psychedelics in the treatment of multiple …
methamphetamine (MDMA) and serotonergic psychedelics in the treatment of multiple …