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Bile acids and the gut microbiota: metabolic interactions and impacts on disease
Despite decades of bile acid research, diverse biological roles for bile acids have been
discovered recently due to developments in understanding the human microbiota. As …
discovered recently due to developments in understanding the human microbiota. As …
Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …
Microbiome diversity protects against pathogens by nutrient blocking
The human gut microbiome plays an important role in resisting colonization of the host by
pathogens, but we lack the ability to predict which communities will be protective. We …
pathogens, but we lack the ability to predict which communities will be protective. We …
Microbiota-mediated colonization resistance: mechanisms and regulation
A dense and diverse microbial community inhabits the gut and many epithelial surfaces.
Referred to as the microbiota, it co-evolved with the host and is beneficial for many host …
Referred to as the microbiota, it co-evolved with the host and is beneficial for many host …
Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets
Bile acids, once considered mere dietary surfactants, now emerge as critical modulators of
macronutrient (lipid, carbohydrate, protein) metabolism and the systemic pro …
macronutrient (lipid, carbohydrate, protein) metabolism and the systemic pro …
Targeting the gut microbiota for cancer therapy
Growing evidence suggests that the gut microbiota modulates the efficacy and toxicity of
cancer therapy, most notably immunotherapy and its immune-related adverse effects. The …
cancer therapy, most notably immunotherapy and its immune-related adverse effects. The …
Gut symbionts alleviate MASH through a secondary bile acid biosynthetic pathway
Q Nie, X Luo, K Wang, Y Ding, S Jia, Q Zhao, M Li… - Cell, 2024 - cell.com
The gut microbiota has been found to play an important role in the progression of metabolic
dysfunction-associated steatohepatitis (MASH), but the mechanisms have not been …
dysfunction-associated steatohepatitis (MASH), but the mechanisms have not been …
Microbiome-based therapeutics
Symbiotic microorganisms inhabiting the gastrointestinal tract promote health by decreasing
susceptibility to infection and enhancing resistance to a range of diseases. In this Review …
susceptibility to infection and enhancing resistance to a range of diseases. In this Review …
Antimicrobial properties of chitosan and chitosan derivatives in the treatment of enteric infections
Antibiotics played an important role in controlling the development of enteric infection.
However, the emergence of antibiotic resistance and gut dysbiosis led to a growing interest …
However, the emergence of antibiotic resistance and gut dysbiosis led to a growing interest …
Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians
Centenarians have a decreased susceptibility to ageing-associated illnesses, chronic
inflammation and infectious diseases,–. Here we show that centenarians have a distinct gut …
inflammation and infectious diseases,–. Here we show that centenarians have a distinct gut …