The plasma membrane and the underlying cortical actin cytoskeleton undergo continuous
dynamic interplay that is responsible for many essential aspects of cell physiology …

Bacterial pathogens exploit a huge range of niches within their hosts. Many pathogens can
invade non-phagocytic cells and survive within a membrane-bound compartment. However …

Conspectus In biology, the function of many molecules is regulated through nonequilibrium
chemical reaction cycles. The prototypical example is the phosphorylation of an amino acid …

Matrix stiffening and myofibroblast resistance to apoptosis are cardinal features of chronic
fibrotic diseases involving diverse organ systems. The interactions between altered tissue …

Some of the key steps in cancer metastasis are the migration and invasion of tumor cells;
these processes require rearrangement of the cytoskeleton. Actin filaments, microtubules …

652 is energetically unfavourable until there is a nucleus of three associating monomers and
in vitro this stage of filament formation is denoted the lag phase. In vivo, ABPs are crucial to …

The combined use of the new technologies of multiphoton-based intravital imaging, the
chemotaxis-mediated collection of invasive cells, and high sensitivity expression profiling …

The actin cytoskeleton drives many essential biological processes, from cell morphogenesis
to motility. Assembly of functional actin networks requires control over the speed at which …

Despite the wealth of different actin structures formed, only two actin nucleation factors are
well established in vertebrates: the Arp2/3 complex and formins. Here, we describe a further …

The actin cytoskeleton is one of the major structural components of the cell. It often
undergoes rapid reorganization and plays crucial roles in a number of dynamic cellular …