The regulation of gene expression is fundamental for life. Whereas the role of transcriptional
regulation of gene expression has been studied for several decades, it has been clear over …

To date, the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has determined 399,600,607 cases and 5,757,562 …

Monoclonal antibodies are a growing class of targeted cancer therapeutics, characterized by
exquisite specificity, long serum half-life, high affinity and immune effector functions. In this …

RNA is a key regulator of almost every cellular process, and the structures adopted by RNA
molecules are thought to be central to their functions. The recent fast-paced evolution of high …

Over the past several decades, messenger RNA (mRNA) vaccines have progressed from a
scepticism-inducing idea to clinical reality. In 2020, the COVID-19 pandemic catalysed the …

The Coronavirus disease-19 (COVID-19) pandemic, caused by severe acute respiratory
syndrome coronavirus-2 (SARS-CoV-2), has impacted human lives in the most profound …

Immunotherapy has emerged as a breakthrough strategy in cancer treatment. mRNA
vaccines are an attractive and powerful immunotherapeutic platform against cancer because …

Abstract The 5′ untranslated region (UTR), a regulatory region at the beginning of a
messenger RNA (mRNA) molecule, plays a crucial role in regulating the translation process …

Abstract mRNA medicine is a new and rapidly develo** field in which the delivery of
genetic information in the form of mRNA is used to direct therapeutic protein production in …

Gene therapy is on its way to revolutionize the treatment of both inherited and acquired
diseases, by transferring nucleic acids to correct a disease-causing gene in the target cells …