Environmental and genetic risk factors for MS: an integrated review
Recent findings have provided a molecular basis for the combined contributions of
multifaceted risk factors for the onset of multiple sclerosis (MS). MS appears to start as a …
multifaceted risk factors for the onset of multiple sclerosis (MS). MS appears to start as a …
Genetics of multiple sclerosis: lessons from polygenicity
Large-scale map** studies have identified 236 independent genetic variants associated
with an increased risk of multiple sclerosis. However, none of these variants are found …
with an increased risk of multiple sclerosis. However, none of these variants are found …
Towards a global view of multiple sclerosis genetics
Multiple sclerosis (MS) is a neuroimmunological disorder of the CNS with a strong heritable
component. The genetic architecture of MS susceptibility is well understood in populations of …
component. The genetic architecture of MS susceptibility is well understood in populations of …
Genomic effects of the vitamin D receptor: potentially the link between vitamin D, immune cells, and multiple sclerosis
Vitamin D has a plethora of functions that are important for the maintenance of general
health and in particular, the functional integrity of the immune system, such as promoting an …
health and in particular, the functional integrity of the immune system, such as promoting an …
Genetics and functional genomics of multiple sclerosis
W Kim, NA Patsopoulos - Seminars in immunopathology, 2022 - Springer
Multiple sclerosis (MS) is an inflammatory neurodegenerative disease with genetic
predisposition. Over the last decade, genome-wide association studies with increasing …
predisposition. Over the last decade, genome-wide association studies with increasing …
The association between disability progression, relapses, and treatment in early relapse onset MS: an observational, multi-centre, longitudinal cohort study
The indirect contribution of multiple sclerosis (MS) relapses to disability worsening
outcomes, and vice-versa, remains unclear. Disease modifying therapies (DMTs) are …
outcomes, and vice-versa, remains unclear. Disease modifying therapies (DMTs) are …
Genetic Variation in WNT9B Increases Relapse Hazard in Multiple Sclerosis
Objective Many multiple sclerosis (MS) genetic susceptibility variants have been identified,
but understanding disease heterogeneity remains a key challenge. Relapses are a core …
but understanding disease heterogeneity remains a key challenge. Relapses are a core …
Ensemble machine learning identifies genetic loci associated with future worsening of disability in people with multiple sclerosis
Limited studies have been conducted to identify and validate multiple sclerosis (MS) genetic
loci associated with disability progression. We aimed to identify MS genetic loci associated …
loci associated with disability progression. We aimed to identify MS genetic loci associated …
Comparing RNA‐sequencing datasets from astrocytes, oligodendrocytes, and microglia in multiple sclerosis identifies novel dysregulated genes relevant to …
SS Drake, A Zaman, T Simas… - WIREs Mechanisms of …, 2023 - Wiley Online Library
Central nervous system (CNS) inflammation is a key factor in multiple sclerosis (MS).
Invasion of peripheral immune cells into the CNS resulting from an unknown signal or …
Invasion of peripheral immune cells into the CNS resulting from an unknown signal or …
Exonic variants of genes related to the vitamin D signaling pathway in the families of familial multiple sclerosis using whole‐exome next generation sequencing
Abstract Introduction Vitamin D (VD) deficiency has been associated with multiple sclerosis
(MS) and other autoimmune diseases (AIDs). However, the effect of the genetics of VD on …
(MS) and other autoimmune diseases (AIDs). However, the effect of the genetics of VD on …