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Polyploidy as a fundamental phenomenon in evolution, development, adaptation and diseases
DNA replication during cell proliferation is 'vertical'copying, which reproduces an initial
amount of genetic information. Polyploidy, which results from whole-genome duplication, is …
amount of genetic information. Polyploidy, which results from whole-genome duplication, is …
Whole-genome doubling in tissues and tumors
The overwhelming majority of proliferating somatic human cells are diploid, and this
genomic state is typically maintained across successive cell divisions. However, failures in …
genomic state is typically maintained across successive cell divisions. However, failures in …
[HTML][HTML] Polyploidy and myc proto-oncogenes promote stress adaptation via epigenetic plasticity and gene regulatory network rewiring
Polyploid cells demonstrate biological plasticity and stress adaptation in evolution;
development; and pathologies, including cardiovascular diseases, neurodegeneration, and …
development; and pathologies, including cardiovascular diseases, neurodegeneration, and …
Tissue homeostasis and non-homeostasis: from cell life cycles to organ states
Although tissue homeostasis—the steady state—implies stability, our organs are in a state of
continual, large-scale cellular flux. This flux underpins an organ's ability to homeostatically …
continual, large-scale cellular flux. This flux underpins an organ's ability to homeostatically …
The antagonistic relationship between apoptosis and polyploidy in development and cancer
One of the important functions of regulated cell death is to prevent cells from inappropriately
acquiring extra copies of their genome, a state known as polyploidy. Apoptosis is the primary …
acquiring extra copies of their genome, a state known as polyploidy. Apoptosis is the primary …
[HTML][HTML] Integrating the study of polyploidy across organisms, tissues, and disease
Polyploidy is a cellular state containing more than two complete chromosome sets. It has
largely been studied as a discrete phenomenon in either organismal, tissue, or disease …
largely been studied as a discrete phenomenon in either organismal, tissue, or disease …
Conserved chamber-specific polyploidy maintains heart function in Drosophila
Developmentally programmed polyploidy (whole-genome duplication) of cardiomyocytes is
common across evolution. Functions of such polyploidy are essentially unknown. Here, in …
common across evolution. Functions of such polyploidy are essentially unknown. Here, in …
An unscheduled switch to endocycles induces a reversible senescent arrest that impairs growth of the Drosophila wing disc
A programmed developmental switch to G/S endocycles results in tissue growth through an
increase in cell size. Unscheduled, induced endocycling cells (iECs) promote wound …
increase in cell size. Unscheduled, induced endocycling cells (iECs) promote wound …
Integrating the Study of Polyploidy Across Organisms, Tissues, and Disease
Polyploidy is a cellular state containing more than two complete chromosome sets. It has
largely been studied as a discrete phenomenon in either organismal, tissue, or disease …
largely been studied as a discrete phenomenon in either organismal, tissue, or disease …
Polyploid superficial uroepithelial bladder barrier cells express features of cellular senescence across the lifespan and are insensitive to senolytics
IM Al‐Naggar, M Antony, D Baker, L Wang… - Aging cell, 2024 - Wiley Online Library
Lower urinary tract dysfunction (LUTD) increases with aging. Ensuing symptoms including
incontinence greatly impact quality of life, isolation, depression, and nursing home …
incontinence greatly impact quality of life, isolation, depression, and nursing home …