The microtubule-based spindle orchestrates chromosome segregation during cell division.
Following more than a century of study, many components and pathways contributing to …

Microtubule-severing enzymes generate internal breaks in microtubules. They are
conserved in eukaryotes from ciliates to mammals, and their function is important in diverse …

Mitotic cells face the challenging tasks of linking kinetochores to growing and shortening
microtubules and actively regulating these dynamic attachments to produce accurate …

PIWI-interacting RNAs (piRNAs) silence retrotransposons in Drosophila germ lines by
associating with the PIWI proteins Argonaute 3 (AGO3), Aubergine (Aub) and Piwi,. piRNAs …

The microtubule cytoskeleton is a dynamic structure in which the lengths of the microtubules
are tightly regulated. One regulatory mechanism is the depolymerization of microtubules by …

Since the discovery of γ-tubulin, attention has focused on its involvement as a microtubule
nucleator at the centrosome. However, mislocalization of γ-tubulin away from the …

For over a century, scientists have strived to understand the mechanisms that govern the
accurate segregation of chromosomes during mitosis. The most intriguing feature of this …

The mitotic spindle is the macromolecular machine that segregates chromosomes to two
daughter cells during mitosis. The major structural elements of the spindle are microtubule …

The kinetochore is a control module that both powers and regulates chromosome
segregation in mitosis and meiosis. The kinetochore-microtubule interface is remarkably …

INTRODUCTION When an egg is fertilized by a sperm, the chromosomes of the mother and
the father become united, and a genetically unique embryo starts to form. A healthy embryo …