Sex differences in endothelial function important to vascular health and overall cardiovascular disease risk across the lifespan
Diseases of the cardiovascular system are the leading cause of morbidity and mortality in
men and women in developed countries, and cardiovascular disease (CVD) is becoming …
men and women in developed countries, and cardiovascular disease (CVD) is becoming …
Matters of the heart: cellular sex differences
Nearly all cardiovascular diseases show sexual dimorphisms in prevalence, presentation,
and outcomes. Until recently, most clinical trials were carried out in males, and many animal …
and outcomes. Until recently, most clinical trials were carried out in males, and many animal …
Genes that escape X chromosome inactivation modulate sex differences in valve myofibroblasts
Background: Aortic valve stenosis is a sexually dimorphic disease, with women often
presenting with sustained fibrosis and men with more extensive calcification. However, the …
presenting with sustained fibrosis and men with more extensive calcification. However, the …
[HTML][HTML] Understanding the role of sex hormones in Cardiovascular kidney metabolic syndrome: toward personalized therapeutic approaches
Cardiovascular kidney metabolic (CKM) syndrome represents a complex interplay of
cardiovascular disease (CVD), chronic kidney disease (CKD), and metabolic comorbidities …
cardiovascular disease (CVD), chronic kidney disease (CKD), and metabolic comorbidities …
Sex-specific characteristics of the microcirculation
The requirements of metabolizing tissue are both continuous and variable; accordingly, the
microvasculature serving that tissue must be similarly dynamic. Just as it is recognized that …
microvasculature serving that tissue must be similarly dynamic. Just as it is recognized that …
Endothelin and the heart in health and diseases
Abstract Endothelin-1 (ET-1), a 21-amino acid peptide, was initially identified in 1988 as a
potent vasoconstrictor and pressor substance isolated from the culture supernatant of …
potent vasoconstrictor and pressor substance isolated from the culture supernatant of …
Hyperuricemia and endothelial function: is it a simple association or do gender differences play a role in this binomial?
T Ciarambino, P Crispino, M Giordano - Biomedicines, 2022 - mdpi.com
The endothelium plays a fundamental role in the biological processes that ensure
physiological vessel integrity, synthesizing numerous substances that are capable of …
physiological vessel integrity, synthesizing numerous substances that are capable of …
Estrogen contributions to microvascular dysfunction evolving to heart failure with preserved ejection fraction
AA Sickinghe, SJA Korporaal, HM Den Ruijter… - Frontiers in …, 2019 - frontiersin.org
Heart failure with preserved ejection fraction (HFpEF) is a syndrome involving microvascular
dysfunction. No treatment is available yet and as the HFpEF patient group is expanding due …
dysfunction. No treatment is available yet and as the HFpEF patient group is expanding due …
Acclimation to a High‐Salt Diet Is Sex Dependent
Background Premenopausal women are less likely to develop hypertension and salt‐related
complications than are men, yet the impact of sex on mechanisms regulating Na+ …
complications than are men, yet the impact of sex on mechanisms regulating Na+ …
Sex differences in regulation of blood pressure
JF Reckelhoff - Sex-Specific Analysis of Cardiovascular Function, 2018 - Springer
Hypertension is one of the leading risk factors for cardiovascular disease, myocardial
infarction, and stroke. There are gender differences in the prevalence of hypertension and in …
infarction, and stroke. There are gender differences in the prevalence of hypertension and in …