Psoriasis is a common chronic inflammatory disease of the skin that is increasingly being
recognized as a systemic inflammatory disorder. Psoriatic arthritis is a well-known …

The presence of symptom clusters, regional differences in disease expression and
similarities with, for example, Crohn's disease suggest multiple pathological pathways are …

Human gut microbiome composition is shaped by multiple factors but the relative
contribution of host genetics remains elusive. Here we examine genotype and microbiome …

The history of the British Isles and Ireland is characterized by multiple periods of major
cultural change, including the influential transformation after the end of Roman rule, which …

Psoriasis is a chronic inflammatory skin disease, the immunologic model of which has been
profoundly revised following recent advances in the understanding of its pathophysiology. In …

Multiple sclerosis is a common disease of the central nervous system in which the interplay
between inflammatory and neurodegenerative processes typically results in intermittent …

Over the past 5 years, advances in high-throughput techniques and studies involving large
cohorts of patients have led to considerable advances in the identification of novel genetic …

The same mutation can have different effects in different individuals. One important reason
for this is that the outcome of a mutation can depend on the genetic context in which it …

Fine-scale genetic variation between human populations is interesting as a signature of
historical demographic events and because of its potential for confounding disease studies …

Genetic factors have been implicated in stroke risk, but few replicated associations have
been reported. We conducted a genome-wide association study (GWAS) for ischemic stroke …