Wet fluidized bed granulation and coating processes have been widely used in the
pharmaceutical and food industries. The complex gas–solid flow coupled with heat and …

Recently, there has been an increase in the use of numerical simulation technology in
pharmaceutical preparation processes. Numerical simulation can contribute to a better …

During the coating process of medicines, premature drying of the spray droplets may cause
losses, as the droplets do not stick to the product. This work addresses two mechanisms that …

This work presents a novel time-scale extrapolation method to predict the amount and
location of the coating material on tablets based on short discrete element method (DEM) …

Abstract The Discrete Element Method (DEM) is commonly used for modeling the flow of
particulate materials. Unfortunately, such detailed simulations are computationally very …

Coating uniformity is crucial for pharmaceutical solid dosages to ensure sufficient stability
and to program drug release behavior. The present study aims to thoroughly investigate the …

Abstract A CFD–DEM coupled with a cohesive contact model is developed for simulation of
a Wurster fluidized bed with heat and mass transfer. First, the water evaporation and …

Tablets are usually spray-coated in the pharmaceutical industry, and coating uniformity is
important for the coating process. In this study, discrete element method-discrete droplet …

Calibration of contact parameters for the DEM approach remains one of the critical obstacles
for an accurate description of powder flows. Ideally, such a calibration approach relies on …

The current study aims to apply an innovative mathematical model based on the discrete
element method to numerically simulate the electrostatic dry powder coating process and to …