Ageing causes a progressive decline in skeletal muscle mass that may lead to decreased
strength and functionality. The term sarcopenia is especially used to characterise this …

Rhabdomyosarcoma, a neoplasm composed of skeletal myoblast-like cells, represents the
most common soft tissue sarcoma in children. The application of intensive …

Although p38 MAPK activation is essential for myogenesis, the upstream signaling
mechanism that activates p38 during myogenesis remains undefined. We recently reported …

A JAK2V617F mutation is frequently found in several BCR/ABL-negative myeloproliferative
disorders. To address the contribution of this mutant to the pathogenesis of these different …

Recent data suggest a physiological role for the proinflammatory cytokine TNF-α in skeletal
muscle regeneration. However, the underlying mechanism is not understood. In the present …

Background Skeletal-muscle differentiation is required for the regeneration of myofibers after
injury. The differentiation capacity of satellite cells is impaired in settings of old age, which is …

Introduction: C2C12 myoblasts undergo in vitro myogenesis to form protein‐rich
multinucleated myotubes. Determining the fraction of total nuclei incorporated into myotubes …

Skeletal muscle differentation is a complex process regulated at multiple levels. This study
addressed the effect of glutathione (GSH) depletion on the transition of murine skeletal …

Background High dosage of dexamethasone (Dex) is an effective treatment for multiple
diseases; however, it is often associated with severe side effects including muscle atrophy …

Skeletal muscle differentiation is mediated by a complex gene expression program requiring
both the muscle-specific transcription factor Myogenin (Myog) and p38α MAPK (p38α) …