The primary cilium as a signaling nexus for growth plate function and subsequent skeletal development
The primary cilium is a solitary, antenna‐like sensory organelle with many important roles in
cartilage and bone development, maintenance, and function. The primary cilium's potential …
cartilage and bone development, maintenance, and function. The primary cilium's potential …
Periosteal progenitors contribute to load-induced bone formation in adult mice and require primary cilia to sense mechanical stimulation
Background The fully developed adult skeleton adapts to mechanical forces by generating
more bone, usually at the periosteal surface. Progenitor cells in the periosteum are believed …
more bone, usually at the periosteal surface. Progenitor cells in the periosteum are believed …
Cigarette smoke induces the risk of metabolic bone diseases: transforming growth factor beta signaling impairment via dysfunctional primary cilia affects migration …
It is well established that smoking has detrimental effects on bone integrity and is a
preventable risk factor for metabolic bone disorders. Following orthopedic surgeries …
preventable risk factor for metabolic bone disorders. Following orthopedic surgeries …
Functional diversity of ciliary proteins in bone development and disease
M Kaku, Y Komatsu - Current Osteoporosis Reports, 2017 - Springer
Abstract Purpose of Review The primary cilium is a non-motile microtubule-based organelle
that senses a diverse range of extracellular signals. While recent studies highlight the …
that senses a diverse range of extracellular signals. While recent studies highlight the …
Primary cilia are necessary for Prx1-expressing cells to contribute to postnatal skeletogenesis
ER Moore, Y Yang, CR Jacobs - Journal of cell science, 2018 - journals.biologists.com
Although Prx1 (also known as PRRX1)-expressing cells and their primary cilia are critical for
embryonic development, they have yet to be studied in the context of postnatal …
embryonic development, they have yet to be studied in the context of postnatal …
A role for primary cilia in coral calcification?
Cilia are evolutionarily conserved organelles that extend from the surface of cells and are
found in diverse organisms from protozoans to multicellular organisms. Motile cilia play …
found in diverse organisms from protozoans to multicellular organisms. Motile cilia play …
Prx1-expressing cells contributing to fracture repair require primary cilia for complete healing in mice
Bone is a dynamic organ that is continuously modified during development, load-induced
adaptation, and fracture repair. Understanding the cellular and molecular mechanisms for …
adaptation, and fracture repair. Understanding the cellular and molecular mechanisms for …
[HTML][HTML] An Emerging Role for Primary Cilia of the Renal Glomerulus: Implications and Considerations for Pathogenesis of Glomerular Diseases
L Fitzsimons - Cell Communication and Signaling in Health and …, 2024 - intechopen.com
Primary cilia are highly specialized, sensory protrusions elaborated from nearly all
eukaryotic cells. Our knowledge of their structure and function continues to evolve, driven by …
eukaryotic cells. Our knowledge of their structure and function continues to evolve, driven by …
An Emerging Role for Primary
L Fitzsimons - Cell Communication and Signaling in Health and …, 2024 - books.google.com
Primary cilia are highly specialized, sensory protrusions elaborated from nearly all
eukaryotic cells. Our knowledge of their structure and function continues to evolve, driven by …
eukaryotic cells. Our knowledge of their structure and function continues to evolve, driven by …
Primary cilia and PTH1R interplay in the regulation of osteogenic actions
JA Ardura, E Martín-Guerrero… - Vitamins and …, 2022 - Elsevier
Primary cilia are subcellular structures specialized in sensing different stimuli in a diversity of
cell types. In bone, the primary cilium is involved in mechanical sensing and transduction of …
cell types. In bone, the primary cilium is involved in mechanical sensing and transduction of …