The T-cell receptor (TCR) functions in both antigen recognition and signal transduction,
which are crucial initial steps of antigen-specific immune responses. TCR integrity is vital for …

Rheumatoid arthritis is a multisystemic auto-inflammatory disease affecting up to 1% of the
population and leading to the destruction of the joints. Evidence exists for the involvement of …

Abstract Objective In mice, CD4+ CD25+ regulatory T cells play a pivotal role in preventing
autoimmunity. Regulatory T cells are also present and functional in healthy humans. We …

Chronic inflammation is accompanied by impaired T-cell immunity. In the mouse, myeloid
cell-associated arginase accounts for the suppression of immune reactivity in various …

CD4+ T cells are critical components of the adaptive immune system. The T cell receptor
(TCR) and co-receptor signaling cascades shape the phenotype and functions of CD4+ T …

Human NK cells may be divided into a CD56 dim subset and a CD56 bright subset. In
peripheral blood, CD56 dim NK cells dominate, whereas in lymph nodes, CD56 bright NK …

Immune system-based approaches for the treatment of malignant disease over the past
decades have often focused on cytolytic effector cells such as cytotoxic T lymphocytes (CTL) …

Introduction Anti-citrullinated peptide antibodies are found in rheumatoid arthritis (RA)
patients with HLA-DRβ chains encoding the shared epitope (SE) sequence. Citrullination …

T cell AgR ζ chain down-regulation associated with T cell dysfunction has been described in
cancer, infectious, and autoimmune diseases. We have previously shown that chronic …

Objective T cells from the majority of patients with systemic lupus erythematosus (SLE)
express significantly lower levels of T cell receptor ζ chain, a critical signaling molecule …