Eukaryotic cells have a highly evolved system of protein secretion, and dysfunction in this
pathway is associated with many diseases including cancer, infection, metabolic disease …

Matrix metalloproteinases (MMPs), originally discovered to function in the breakdown of
extracellular matrix proteins, have gained the status of regulatory proteases in signaling …

Acute myeloid leukemia (AML) is a severe and often fatal systemic malignancy. Malignant
cells are capable of esca** host immune surveillance by inactivating cytotoxic lymphoid …

Human cancer cells operate a variety of effective molecular and signaling mechanisms
which allow them to escape host immune surveillance and thus progress the disease. We …

Several cell surface molecules including signalling receptors are internalized by clathrin-
independent endocytosis. How this process is initiated, how cargo proteins are sorted and …

In contrast to the well established multiple cellular roles of membrane vesicles in eukaryotic
cell biology, outer membrane vesicles (OMV) produced via blebbing of prokaryotic …

Acute myeloid leukemia (AML), a blood/bone marrow cancer, is a severe and often fatal
malignancy. AML cells are capable of impairing the anti-cancer activities of cytotoxic …

The beta-galactoside binding lectin galectin-3 (Gal3) is found intracellularly and in the
extracellular space. Secretion of this lectin is mediated independently of the secretory …

Recent advances in polymer science are enabling substantial progress in
nanobiotechnology, particularly in the design of new tools for enhanced understanding of …

Rational drug design is predicated on knowledge of the three-dimensional structure of the
protein− ligand complex and the thermodynamics of ligand binding. Despite the …