Over 10% of the global population suffers from kidney disease. However, only kidney
replacement therapies, which burden medical expenses, are currently effective in treating …

Aquaporins (AQPs) are integral membrane proteins and found in all living organisms from
bacteria to human. AQPs mainly involved in the transmembrane diffusion of water as well as …

The pathophysiology of sepsis involves complex cytokine and inflammatory mediator
networks. Downregulation of endothelial nitric oxide synthase contributes to sepsis-induced …

Background Mortality in sepsis is most often attributed to the development of multiple organ
failure. In sepsis, inflammation-mediated endothelial activation, defined as a …

Background: Septic acute kidney injury is considered as a severe and frequent complication
that occurs during sepsis. The present study was performed to understand the role of miR-22 …

The current definition of acute kidney injury (AKI) is generic and, based only on markers of
function, is unsuitable for guiding individualized treatment. AKI is a complex syndrome with …

BACKGROUND Oleanolic acid (OA) is a pentacyclic triterpenoid compound that is present at
high levels in olive oil and has several promising pharmacological effects, such as liver …

Background Sepsis is a common cause of death in intensive care units worldwide. Due to
the high complexity of this immunological syndrome development of novel therapeutic …

Ischemia reperfusion injury (IRI) is the predominant tissue insult associated with organ
transplantation. Treatment with carbon monoxide (CO) modulates the innate immune …

Background Early acute kidney injury (AKI) in severely burned patients predicts a high
mortality that is multi-factorial. Hydrogen has been reported to alleviate organ injury via …