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Saga of Mcl-1: regulation from transcription to degradation
The members of the Bcl-2 family are the central regulators of various cell death modalities.
Some of these proteins contribute to apoptosis, while others counteract this type of …
Some of these proteins contribute to apoptosis, while others counteract this type of …
Apoptotic signaling by c-MYC
Abstract c-MYC has a pivotal function in growth control, differentiation and apoptosis, and its
abnormal expression is associated with many tumors. Overexpression of c-MYC sensitizes …
abnormal expression is associated with many tumors. Overexpression of c-MYC sensitizes …
Bacteroides acidifaciens in the gut plays a protective role against CD95-mediated liver injury
H Wang, Q Wang, C Yang, M Guo, X Cui, Z **g… - Gut …, 2022 - Taylor & Francis
The intestinal flora plays an important role in the development of many human and animal
diseases. Microbiome association studies revealed the potential regulatory function of …
diseases. Microbiome association studies revealed the potential regulatory function of …
Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype
Identification of specific gene expression signatures characteristic of oncogenic pathways is
an important step toward molecular classification of human malignancies. Aberrant …
an important step toward molecular classification of human malignancies. Aberrant …
[PDF][PDF] Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factor β–induced apoptosis
Hepatocytes in culture are a valuable tool to investigate mechanisms involved in the
response of the liver to cytokines. However, it is well established that hepatocytes cultured …
response of the liver to cytokines. However, it is well established that hepatocytes cultured …
Survival and apoptosis: a dysregulated balance in liver cancer
Abstract Background/Aims: Dysregulation of the balance between proliferation and cell
death represents a protumorigenic principle in human hepatocarcinogenesis. This article …
death represents a protumorigenic principle in human hepatocarcinogenesis. This article …
The promise of TRAIL—potential and risks of a novel anticancer therapy
R Koschny, H Walczak, TM Ganten - Journal of molecular medicine, 2007 - Springer
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising new
anticancer biotherapeutic. As shown by many preclinical studies, TRAIL efficiently induces …
anticancer biotherapeutic. As shown by many preclinical studies, TRAIL efficiently induces …
Mcl-1 interacts with truncated Bid and inhibits its induction of cytochrome c release and its role in receptor-mediated apoptosis
Engagement of death receptors such as tumor necrosis factor-R1 and Fas brings about the
cleavage of cytosolic Bid to truncated Bid (tBid), which translocates to mitochondria to …
cleavage of cytosolic Bid to truncated Bid (tBid), which translocates to mitochondria to …
Cyclooxygenase-2 inhibition induces apoptosis signaling via death receptors and mitochondria in hepatocellular carcinoma
Abstract Inhibition of cyclooxygenase (COX)-2 elicits chemopreventive and therapeutic
effects in solid tumors that are coupled with the induction of apoptosis in tumor cells. We …
effects in solid tumors that are coupled with the induction of apoptosis in tumor cells. We …
AKT activator SC79 protects hepatocytes from TNF-α-mediated apoptosis and alleviates d-Gal/LPS-induced liver injury
ZT **g, W Liu, CR Xue, SX Wu… - American Journal …, 2019 - journals.physiology.org
Tumor necrosis factor-α (TNF-α) is a highly pleiotropic cytokine executing biological
functions as diverse as cell proliferation, metabolic activation, inflammatory responses, and …
functions as diverse as cell proliferation, metabolic activation, inflammatory responses, and …