There is increasing appreciation that non-neuronal cells contribute to the initiation,
progression and pathology of diverse neurodegenerative disorders. This Review focuses on …

Infrared spectroscopy is a powerful tool widely used in research and industry for a label-free
and unambiguous identification of molecular species. Inconveniently, its application to …

Summary Apolipoprotein E4 (APOE4) is the greatest known genetic risk factor for
develo** sporadic Alzheimer's disease. How the interaction of APOE4 microglia with …

Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

Lipids are a fundamental class of organic molecules implicated in a wide range of biological
processes related to their structural diversity, and based on this can be broadly classified …

Exosomes are nano-sized vesicles that serve as mediators for intercellular communication
through the delivery of cargo, including protein, lipids, nucleic acids or other cellular …

Efficient cytosolic delivery is a significant hurdle when using short interfering RNA (siRNA) in
therapeutic applications. Here we show that cholesterol-rich exosomes are prone to entering …

Serotonin regulates a wide variety of brain functions and behaviors. Here, we synthesize
previous findings that serotonin regulates executive function, sensory gating, and social …

Parkinson's disease (PD) is the second most common neurodegenerative disease, the main
pathological hallmark of which is the accumulation of α-synuclein (α-syn) and the formation …

Sphingolipids are highly enriched in the nervous system where they are pivotal constituents
of the plasma membranes and are important for proper brain development and functions …