[HTML][HTML] Self-nano-emulsifying drug-delivery systems: From the development to the current applications and challenges in oral drug delivery
AB Buya, A Beloqui, PB Memvanga, V Préat - Pharmaceutics, 2020 - mdpi.com
Approximately one third of newly discovered drug molecules show insufficient water
solubility and therefore low oral bio-availability. Self-nano-emulsifying drug-delivery systems …
solubility and therefore low oral bio-availability. Self-nano-emulsifying drug-delivery systems …
Predicting biophysical properties of small molecules from chromatographic measurements and the solvation parameter model
CF Poole, SN Atapattu - Journal of Chromatography A, 2024 - Elsevier
Biopartitioning processes are challenging to study and often require the sacrifice of multiple
animals. Therefore, it is more practical and cost-effective to correlate these processes with …
animals. Therefore, it is more practical and cost-effective to correlate these processes with …
Corneal Permeability and Uptake of Twenty-Five Drugs: Species Comparison and Quantitative Structure–Permeability Relationships
CP Santana, BA Matter, MA Patil, A Silva-Cunha… - Pharmaceutics, 2023 - mdpi.com
The purpose of this study was to determine corneal permeability and uptake in rabbit,
porcine, and bovine corneas for twenty-five drugs using an N-in-1 (cassette) approach and …
porcine, and bovine corneas for twenty-five drugs using an N-in-1 (cassette) approach and …
Investigation of the uptake and transport of polysaccharide from Se-enriched Grifola frondosa in Caco-2 cells model
Q **ang, W Zhang, Q Li, J Zhao, W Feng, T Zhao… - International Journal of …, 2020 - Elsevier
A variety of beneficial pharmacological activities have been reported for Se-enriched Grifola
frondosa polysaccharides. However, little has been reported on its absorption, and its …
frondosa polysaccharides. However, little has been reported on its absorption, and its …
[HTML][HTML] In silico prediction of PAMPA effective permeability using a two-QSAR approach
CT Chi, MH Lee, CF Weng, MK Leong - International journal of molecular …, 2019 - mdpi.com
Oral administration is the preferred and predominant route of choice for medication. As such,
drug absorption is one of critical drug metabolism and pharmacokinetics (DM/PK) …
drug absorption is one of critical drug metabolism and pharmacokinetics (DM/PK) …
Uptake and transport of naringenin and its antioxidant effects in human intestinal epithelial Caco-2 cells
ZD Zhang, Q Tao, Z Qin, XW Liu, SH Li, LX Bai… - Frontiers in …, 2022 - frontiersin.org
Naringenin, a flavanone, has been reported for a wide range of pharmacological activities.
However, there are few reports on the absorption, transport and antioxidant effects of …
However, there are few reports on the absorption, transport and antioxidant effects of …
[HTML][HTML] Extending the limitations in the prediction of PAMPA permeability with machine learning algorithms
Gastrointestinal absorption is a key factor amongst the ADME-related (absorption,
distribution, metabolism and excretion) pharmacokinetic properties; therefore, it has a major …
distribution, metabolism and excretion) pharmacokinetic properties; therefore, it has a major …
[HTML][HTML] Human artificial membranes in (bio) analytical science: Potential for in vitro prediction of intestinal absorption-A review
EJ Carrasco-Correa, J Ruiz-Allica… - TrAC Trends in …, 2021 - Elsevier
Artificial membranes for investigation of the human absorption (oral, dermal or respiratory) of
target organic compounds are aimed at mimicking the interactions occurring at and within …
target organic compounds are aimed at mimicking the interactions occurring at and within …
[HTML][HTML] Recent advances on molecular dynamics-based techniques to address drug membrane permeability with atomistic detail
AMM Gomes, PJ Costa, M Machuqueiro - BBA advances, 2023 - Elsevier
Several factors affect the passive membrane permeation of small molecules, including size,
charge, pH, or the presence of specific chemical groups. Understanding these features is …
charge, pH, or the presence of specific chemical groups. Understanding these features is …
In silico–in vitro estimation of lipophilicity and permeability association for succinimide derivatives using chromatographic anisotropic systems and parallel artificial …
D Vidović, N Milošević, N Pavlović… - Biomedical …, 2022 - Wiley Online Library
Passive permeability is one of the key features that determine absorbability and one of the
most studied properties in the early phases of drug development. Newly synthesized …
most studied properties in the early phases of drug development. Newly synthesized …