By changing the electron density at donor sites (also called adsorption or coordination sites),
the substituents significantly impact the coordination proficiency of organic inhibitors. The …

Limited understanding of human proteoforms with complex posttranslational modifications
and the underlying mechanisms poses a major obstacle to research on human health and …

Membrane‐associated D‐proteins are an important class of synthetic molecules needed for
D‐peptide drug discovery, but their chemical synthesis using canonical ligation methods …

Rechargeable batteries are of great significance for alleviating the growing energy crisis by
providing efficient and sustainable energy storage solutions. However, the multiple issues …

The influence of catalysis on the development of modern science and industry cannot be
overestimated. Production of pharmaceutical substances and drugs, 1, 2 the oil industry, 3 …

Small molecules, including therapeutic drugs and tracer molecules, play a vital role in
biological processing, disease treatment and diagnosis, and have inspired various …

Comprehensive Summary Expressed protein ligation (EPL) provides a powerful tool to
access large‐size proteins with precise structures. Existing methods for constructing the …

Abstract The 2-hydroxy-4-methoxybenzyl (Hmb) backbone modification can prevent amide
bond-mediated side-reactions (eg, aspartimide formation, peptide aggregation) by installing …

S‐adenosylmethionine‐dependent methyltransferases are involved in countless biological
processes, including signal transduction, epigenetics, natural product biosynthesis, and …

The precise modification or functionalization of the protein C-terminus is essential but full of
challenges. Herein, a chemical approach to modify the C-terminus is developed by fusing a …