Autophagy and apoptosis are basic physiologic processes contributing to the maintenance
of cellular homeostasis. Autophagy encompasses pathways that target long-lived cytosolic …

Synapses are essential components of neurons and allow information to travel coordinately
throughout the nervous system to adjust behavior to environmental stimuli and to control …

The basal forebrain cholinergic complex comprising medial septum, horizontal and vertical
diagonal band of Broca, and nucleus basalis of Meynert provides the mayor cholinergic …

In Alzheimer's disease (AD) brain, exposure of axons to Aβ causes pathogenic changes that
spread retrogradely by unknown mechanisms, affecting the entire neuron. We found that …

Introduction• Protein aggregation‐'Toxic oligomer'hypothesis‐Protein (mis) folding‐
Proteostasis and molecular chaperones‐Protein misfolding and endoplasmic reticulum …

The decline observed during aging involves multiple factors that influence several systems.
It is the case for learning and memory processes which are severely reduced with aging. It is …

The chemistry of Alzheimer’s disease - Chemical Society Reviews (RSC Publishing) DOI:10.1039/B807980N
Royal Society of Chemistry View PDF VersionPrevious ArticleNext Article DOI: 10.1039/B807980N …

Since its discovery, brain-derived neurotrophic factor (BDNF) has spawned a literature that
now spans 35 years of research. While all neurotrophins share considerable overlap in …

Introduction• Insulin, IGF‐1 in the brain• Glucose metabolism and AD• The insulin and IGF‐1
system in AD• The insulin and oxidative stress in AD• The insulin and IGF‐1R system and τ …

Injury or insult to the adult nervous system often results in reactivation of signaling pathways
that are normally only active during development. The p75 neurotrophin receptor (p75 NTR) …