Cross-talk between skeletal muscle and immune cells: muscle-derived mediators and metabolic implications

NJ Pillon, PJ Bilan, LN Fink… - American Journal of …, 2013‏ - journals.physiology.org
Skeletal muscles contain resident immune cell populations and their abundance and type is
altered in inflammatory myopathies, endotoxemia or different types of muscle injury/insult …

Is the gut microbiota a new factor contributing to obesity and its metabolic disorders?

K Harris, A Kassis, G Major, CJ Chou - Journal of obesity, 2012‏ - Wiley Online Library
The gut microbiota refers to the trillions of microorganisms residing in the intestine and is
integral in multiple physiological processes of the host. Recent research has shown that gut …

High-intensity exercise training increases the diversity and metabolic capacity of the mouse distal gut microbiota during diet-induced obesity

E Denou, K Marcinko, MG Surette… - American Journal …, 2016‏ - journals.physiology.org
Diet and exercise underpin the risk of obesity-related metabolic disease. Diet alters the gut
microbiota, which contributes to aspects of metabolic disease during obesity. Repeated …

The role of gut microbiota on insulin resistance

AM Caricilli, MJA Saad - Nutrients, 2013‏ - mdpi.com
The development of obesity and insulin resistance has been extensively studied in the last
decades, but the mechanisms underlying these alterations are still not completely …

NOD1 activators link innate immunity to insulin resistance

JD Schertzer, AK Tamrakar, JG Magalhães… - Diabetes, 2011‏ - diabetesjournals.org
OBJECTIVE Insulin resistance associates with chronic inflammation, and participatory
elements of the immune system are emerging. We hypothesized that bacterial elements …

Implication of inflammatory signaling pathways in obesity-induced insulin resistance

JF Tanti, F Ceppo, J Jager, F Berthou - Frontiers in endocrinology, 2013‏ - frontiersin.org
Obesity is characterized by the development of a low-grade chronic inflammatory state in
different metabolic tissues including adipose tissue and liver. This inflammation develops in …

Mitochondrial reactive oxygen species in infection and immunity

A Mukherjee, KK Ghosh, S Chakrabortty, B Gulyás… - Biomolecules, 2024‏ - mdpi.com
Reactive oxygen species (ROS) contain at least one oxygen atom and one or more unpaired
electrons and include singlet oxygen, superoxide anion radical, hydroxyl radical …

Muramyl dipeptide-based postbiotics mitigate obesity-induced insulin resistance via IRF4

JF Cavallari, MD Fullerton, BM Duggan, KP Foley… - Cell metabolism, 2017‏ - cell.com
Intestinal dysbiosis contributes to obesity and insulin resistance, but intervening with
antibiotics, prebiotics, or probiotics can be limited by specificity or sustained changes in …

Innate sensors of pathogen and stress: linking inflammation to obesity

C **, RA Flavell - Journal of Allergy and Clinical Immunology, 2013‏ - Elsevier
Pathogen and nutrient response pathways are evolutionarily conserved and highly
integrated to regulate metabolic and immune homeostasis. Excessive nutrients can be …

Defective NOD 2 peptidoglycan sensing promotes diet‐induced inflammation, dysbiosis, and insulin resistance

E Denou, K Lolmède, L Garidou, C Pomie… - EMBO molecular …, 2015‏ - embopress.org
Pattern recognition receptors link metabolite and bacteria‐derived inflammation to insulin
resistance during obesity. We demonstrate that NOD 2 detection of bacterial cell wall …