In theory, in vitro and in vivo models for human gliomas have great potential to not only
enhance our understanding of glioma biology, but also to facilitate the development of novel …

Abstract Isocitrate dehydrogenase 1 and 2 (IDH1/2) are key enzymes in cellular metabolism,
epigenetic regulation, redox states, and DNA repair. IDH1/2 mutations are causal in the …

Mutations, deletions, and changes in copy number of mitochondrial DNA (mtDNA), are
observed throughout cancers. Here, we survey mtDNA copy number variation across 22 …

During sprouting angiogenesis, an individual endothelial tip cell grows out from a pre-
existing vascular network and guides following and proliferating stalk cells to form a new …

Patient-based cancer models are essential tools for studying tumor biology and for the
assessment of drug responses in a translational context. We report the establishment a large …

For many intraoperative decisions surgeons depend on frozen section pathology, a
technique developed over 150 y ago. Technical innovations that permit rapid molecular …

Mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are key events in the
development of glioma, acute myeloid leukemia (AML), chondrosarcoma, intrahepatic …

Heterozygous mutations in NADP‐dependent isocitrate dehydrogenases (IDH) define the
large majority of diffuse gliomas and are associated with hypermethylation of DNA and …

Isocitrate dehydrogenase (IDH) is an essential enzyme for cellular respiration in the
tricarboxylic acid (TCA) cycle. Recurrent mutations in IDH1 or IDH2 are prevalent in several …

The most frequently mutated metabolic genes in human cancer are those encoding the
enzymes isocitrate dehydrogenase 1 (IDH1) and IDH2; these mutations have so far been …