Patients with isolated rapid-eye-movement sleep behaviour disorder (RBD) are commonly
regarded as being in the early stages of a progressive neurodegenerative disease involving …

With the advent of the genetic era in Parkinson's disease (PD) research in 1997, α-synuclein
was identified as an important player in a complex neurodegenerative disease that affects> …

Braak's hypothesis has been extremely influential over the last two decades. However,
neuropathological and clinical evidence suggest that the model does not conform to all …

Objective This study was undertaken to follow up predictive factors for α‐synuclein–related
neurodegenerative diseases in a multicenter cohort of idiopathic/isolated rapid eye …

Rapid-eye movement (REM) sleep behavior disorder (RBD), enactment of dreams during
REM sleep, is an early clinical symptom of alpha-synucleinopathies and defines a more …

As neuroprotective therapies continue to be advanced against neurodegenerative
synucleinopathies, such as Parkinson disease (PD), dementia with Lewy bodies (DLBs) …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by both motor and
non-motor symptoms (NMS). NMS including sleep disturbances, depression, anxiety, and …

This manuscript presents an overview of REM sleep behaviour disorder (RBD) with a
special focus on European contributions. After an introduction examining the history of the …

Purpose of review Rapid eye movement (REM) sleep behaviour disorder (RBD) is
considered the expression of the initial neurodegenerative process underlying …

Genome-wide association studies (GWAS) have identified numerous loci associated with
Parkinson's disease. The specific genes and variants that drive the associations within the …