Proteins adopt different higher-order structures (HOS) to enable their unique biological
functions. Understanding the complexities of protein higher-order structures and dynamics …

▪ Abstract The energy landscape theory of protein folding is a statistical description of a
protein's potential surface. It assumes that folding occurs through organizing an ensemble of …

A grand challenge in the field of structural biology is to design and engineer proteins that
exhibit targeted functions. Although much success on this front has been achieved, design …

General principles of protein structure, stability, and folding kinetics have recently been
explored in computer simulations of simple exact lattice models. These models represent …

Publisher Summary This chapter describes the present state of the studies of the molten
globule state and its role in protein folding and physiological processes. Recent data on the …

Vibrational dynamics of folded proteins is studied using a Gaussian model in which the
protein is viewed as a network, residues representing the junctions, and the connectivity …

Publisher Summary This chapter summarizes the experimental information on protein
energetics. This field is develo** fast and the concept of the energetics of protein structure …

Helix‐cap** motifs are specific patterns of hydrogen bonding and hydrophobic
interactions found at or near the ends of helices in both proteins and peptides. In an α‐helix …

Preparation of biological macromolecules in the pure state requires that cells be disrupted,
releasing and mixing the contents. Only the most stable and highly structured molecules can …

In this review, we shall outline the basic principles Ž. of circular dichroism CD and indicate
the types of structural information relevant to the study of the Ž. folding and unfolding or …