Genomic instability is the hallmark of various cancers with the increasing accumulation of
DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is …

DNA damage is a double-edged sword in cancer cells. On the one hand, DNA damage
exacerbates gene mutation frequency and cancer risk. Mutations in key DNA repair genes …

Cardiac arterial bulbs of Skipjack tuna (Katsuwonus pelamis) are rich in elastin, and its
hydrolysates are high quality raw materials for daily cosmetics. In order to effectively utilizing …

Senescent cells accumulate with age in vertebrates and promote aging largely through their
senescence‐associated secretory phenotype (SASP). Many types of stress induce …

Profound global loss of DNA methylation is a hallmark of many cancers. One potential
consequence of this is the reactivation of transposable elements (TEs) which could stimulate …

Aberrant induction of type I IFN is a hallmark of the inherited encephalopathy Aicardi-
Goutières syndrome (AGS), but the mechanisms triggering disease in the human central …

The idea that chemotherapy can be used in combination with immunotherapy may seem
somewhat counterproductive, as it can theoretically eliminate the immune cells needed for …

In response to persistent DNA damage, induction into cell senescence promotes an
immunogenic program which facilitates immune clearance of these damaged cells. Under …

Neutrophil (PMN) infiltration of the intestinal mucosa is a hallmark of tissue injury associated
with inflammatory bowel diseases (IBDs). The pathological effects of PMNs are largely …

In the last few years, immunotherapy has transformed the way we treat solid tumors,
including melanoma, lung, head neck, breast, renal, and bladder cancers. Durable …