Overweight and obesity in pregnancy: their impact on epigenetics

C Reichetzeder - European journal of clinical nutrition, 2021 - nature.com
Over the last few decades, the prevalence of obesity has risen to epidemic proportions
worldwide. Consequently, the number of obesity in pregnancy has risen drastically …

Perspectives and challenges of epigenetic determinants of childhood obesity: a systematic review

R Alfano, O Robinson, E Handakas, TS Nawrot… - Obesity …, 2022 - Wiley Online Library
The tremendous increase in childhood obesity prevalence over the last few decades cannot
merely be explained by genetics and evolutionary changes in the genome, implying that …

Human milk exosomal microRNA: associations with maternal overweight/obesity and infant body composition at 1 month of life

KB Shah, SD Chernausek, LD Garman, NP Pezant… - Nutrients, 2021 - mdpi.com
Among all the body fluids, breast milk is one of the richest sources of microRNAs (miRNAs).
MiRNAs packaged within the milk exosomes are bioavailable to breastfeeding infants. The …

Whole transcriptome expression profiles in placenta samples from women with gestational diabetes mellitus

L Tang, P Li, L Li - Journal of diabetes investigation, 2020 - Wiley Online Library
Abstract Aims/Introduction Non‐coding ribonucleic acids (ncRNAs) have recently been
shown to be involved in various biological processes. However, most of these ncRNAs are …

Role of microRNAs in trophoblast invasion and spiral artery remodeling: implications for preeclampsia

H Hayder, Y Shan, Y Chen, JA O'Brien… - Frontiers in Cell and …, 2022 - frontiersin.org
It is now well-established that microRNAs (miRNAs) are important regulators of gene
expression. The role of miRNAs in placental development and trophoblast function is …

Primate fetal hepatic responses to maternal obesity: epigenetic signalling pathways and lipid accumulation

S Puppala, C Li, JP Glenn, R Saxena… - The Journal of …, 2018 - Wiley Online Library
Key points Maternal obesity (MO) and exposure to a high‐fat, high‐simple‐carbohydrate diet
during pregnancy predisposes offspring to obesity, metabolic and cardiovascular disorders …

Breast milk supply of microRNA associated with leptin and adiponectin is affected by maternal overweight/obesity and influences infancy BMI

R Zamanillo, J Sánchez, F Serra, A Palou - Nutrients, 2019 - mdpi.com
Breast milk constitutes a dietary source of leptin, adiponectin and microRNAs (miRNAs) for
newborns. Expression of miRNAs previously associated with maternal obesity, leptin or …

The role of non-coding RNAs in the human placenta

M Žarković, F Hufsky, UR Markert, M Marz - Cells, 2022 - mdpi.com
Non-coding RNAs (ncRNAs) play a central and regulatory role in almost all cells, organs,
and species, which has been broadly recognized since the human ENCODE project and …

[HTML][HTML] Placental microRNAs: Responders to environmental chemicals and mediators of pathophysiology of the human placenta

KA Addo, N Palakodety, HJ Hartwell, A Tingare… - Toxicology Reports, 2020 - Elsevier
MicroRNAs (miRNAs) are epigenetic modifiers that play an important role in the regulation of
the expression of genes across the genome. miRNAs are expressed in the placenta as well …

Placental biomarkers for assessing fetal health

I Manokhina, GF Del Gobbo, C Konwar… - Human Molecular …, 2017 - academic.oup.com
The placenta is a multifunctional organ that regulates key aspects of pregnancy
maintenance and fetal development. As the placenta is in direct contact with maternal blood …