The therapeutic age of the neonatal Fc receptor

M Pyzik, LK Kozicky, AK Gandhi… - Nature Reviews …, 2023 - nature.com
IgGs are essential soluble components of the adaptive immune response that evolved to
protect the body from infection. Compared with other immunoglobulins, the role of IgGs is …

The neonatal Fc receptor (FcRn): a misnomer?

M Pyzik, KMK Sand, JJ Hubbard, JT Andersen… - Frontiers in …, 2019 - frontiersin.org
Antibodies are essential components of an adaptive immune response. Immunoglobulin G
(IgG) is the most common type of antibody found in circulation and extracellular fluids …

Nipocalimab in early-onset severe hemolytic disease of the fetus and newborn

KJ Moise Jr, LE Ling, D Oepkes, E Tiblad… - … England Journal of …, 2024 - Mass Medical Soc
Background In early-onset severe hemolytic disease of the fetus and newborn (HDFN),
transplacental transfer of maternal antierythrocyte IgG alloantibodies causes fetal anemia …

Pharmacotherapy of generalized myasthenia gravis with special emphasis on newer biologicals

D Menon, V Bril - Drugs, 2022 - Springer
Myasthenia gravis (MG) is a chronic, fluctuating, antibody-mediated autoimmune disorder
directed against the post-synaptic neuromuscular junctions of skeletal muscles, resulting in …

Advances and ongoing research in the treatment of autoimmune neuromuscular junction disorders

JJGM Verschuuren, J Palace, H Murai… - The Lancet …, 2022 - thelancet.com
Summary Myasthenia gravis and Lambert-Eaton myasthenic syndrome are antibody-
mediated autoimmune diseases of the neuromuscular junction that usually present with …

Phase 2 study of efgartigimod, a novel FcRn antagonist, in adult patients with primary immune thrombocytopenia

AC Newland, B Sánchez‐González… - American journal of …, 2020 - Wiley Online Library
Primary immune thrombocytopenia (ITP) is an acquired autoimmune bleeding disorder,
characterized by a low platelet count (< 100× 109/L) in the absence of other causes …

The ligands for human IgG and their effector functions

SW de Taeye, T Rispens, G Vidarsson - Antibodies, 2019 - mdpi.com
Activation of the humoral immune system is initiated when antibodies recognize an antigen
and trigger effector functions through the interaction with Fc engaging molecules. The most …

[HTML][HTML] Next-generation Fc receptor–targeting biologics for autoimmune diseases

AW Zuercher, R Spirig, AB Morelli, T Rowe… - Autoimmunity …, 2019 - Elsevier
In recent years, there has been a surge in the research and development of novel molecules
as potential therapeutic alternatives to traditional treatments (such as intravenous …

Clinical significance of serum albumin and implications of FcRn inhibitor treatment in IgG-mediated autoimmune disorders

ES Ward, D Gelinas, E Dreesen… - Frontiers in …, 2022 - frontiersin.org
Serum albumin (SA), the most abundant soluble protein in the body, maintains plasma
oncotic pressure and regulates the distribution of vascular fluid and has a range of other …

[HTML][HTML] Neonatal Fc receptor in human immunity: Function and role in therapeutic intervention

DD Patel, JB Bussel - Journal of Allergy and Clinical Immunology, 2020 - Elsevier
The humoral immune response provides specific, long-lived protection against invading
pathogens, via immunoglobulin production and other memory functions. IgG, the most …