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The therapeutic age of the neonatal Fc receptor
IgGs are essential soluble components of the adaptive immune response that evolved to
protect the body from infection. Compared with other immunoglobulins, the role of IgGs is …
protect the body from infection. Compared with other immunoglobulins, the role of IgGs is …
The neonatal Fc receptor (FcRn): a misnomer?
M Pyzik, KMK Sand, JJ Hubbard, JT Andersen… - Frontiers in …, 2019 - frontiersin.org
Antibodies are essential components of an adaptive immune response. Immunoglobulin G
(IgG) is the most common type of antibody found in circulation and extracellular fluids …
(IgG) is the most common type of antibody found in circulation and extracellular fluids …
Nipocalimab in early-onset severe hemolytic disease of the fetus and newborn
KJ Moise Jr, LE Ling, D Oepkes, E Tiblad… - … England Journal of …, 2024 - Mass Medical Soc
Background In early-onset severe hemolytic disease of the fetus and newborn (HDFN),
transplacental transfer of maternal antierythrocyte IgG alloantibodies causes fetal anemia …
transplacental transfer of maternal antierythrocyte IgG alloantibodies causes fetal anemia …
Pharmacotherapy of generalized myasthenia gravis with special emphasis on newer biologicals
D Menon, V Bril - Drugs, 2022 - Springer
Myasthenia gravis (MG) is a chronic, fluctuating, antibody-mediated autoimmune disorder
directed against the post-synaptic neuromuscular junctions of skeletal muscles, resulting in …
directed against the post-synaptic neuromuscular junctions of skeletal muscles, resulting in …
Advances and ongoing research in the treatment of autoimmune neuromuscular junction disorders
JJGM Verschuuren, J Palace, H Murai… - The Lancet …, 2022 - thelancet.com
Summary Myasthenia gravis and Lambert-Eaton myasthenic syndrome are antibody-
mediated autoimmune diseases of the neuromuscular junction that usually present with …
mediated autoimmune diseases of the neuromuscular junction that usually present with …
Phase 2 study of efgartigimod, a novel FcRn antagonist, in adult patients with primary immune thrombocytopenia
AC Newland, B Sánchez‐González… - American journal of …, 2020 - Wiley Online Library
Primary immune thrombocytopenia (ITP) is an acquired autoimmune bleeding disorder,
characterized by a low platelet count (< 100× 109/L) in the absence of other causes …
characterized by a low platelet count (< 100× 109/L) in the absence of other causes …
The ligands for human IgG and their effector functions
Activation of the humoral immune system is initiated when antibodies recognize an antigen
and trigger effector functions through the interaction with Fc engaging molecules. The most …
and trigger effector functions through the interaction with Fc engaging molecules. The most …
[HTML][HTML] Next-generation Fc receptor–targeting biologics for autoimmune diseases
AW Zuercher, R Spirig, AB Morelli, T Rowe… - Autoimmunity …, 2019 - Elsevier
In recent years, there has been a surge in the research and development of novel molecules
as potential therapeutic alternatives to traditional treatments (such as intravenous …
as potential therapeutic alternatives to traditional treatments (such as intravenous …
Clinical significance of serum albumin and implications of FcRn inhibitor treatment in IgG-mediated autoimmune disorders
Serum albumin (SA), the most abundant soluble protein in the body, maintains plasma
oncotic pressure and regulates the distribution of vascular fluid and has a range of other …
oncotic pressure and regulates the distribution of vascular fluid and has a range of other …
[HTML][HTML] Neonatal Fc receptor in human immunity: Function and role in therapeutic intervention
DD Patel, JB Bussel - Journal of Allergy and Clinical Immunology, 2020 - Elsevier
The humoral immune response provides specific, long-lived protection against invading
pathogens, via immunoglobulin production and other memory functions. IgG, the most …
pathogens, via immunoglobulin production and other memory functions. IgG, the most …