Altered GABA-mediated information processing and cognitive dysfunctions in depression and other brain disorders
Cognitive dysfunctions, including impaired attention, learning, memory, planning and
problem solving, occur in depressive episodes, often persist during remission, predict …
problem solving, occur in depressive episodes, often persist during remission, predict …
Sex differences: Transcriptional signatures of stress exposure in male and female brains
More than two‐thirds of patients suffering from stress‐related disorders are women but over
two‐thirds of suicide completers are men. These are just some examples of the many sex …
two‐thirds of suicide completers are men. These are just some examples of the many sex …
Cell type specific transcriptomic differences in depression show similar patterns between males and females but implicate distinct cell types and genes
Major depressive disorder (MDD) is a common, heterogenous, and potentially serious
psychiatric illness. Diverse brain cell types have been implicated in MDD etiology …
psychiatric illness. Diverse brain cell types have been implicated in MDD etiology …
Plasticity of synapses and reward circuit function in the genesis and treatment of depression
SM Thompson - Neuropsychopharmacology, 2023 - nature.com
What changes in brain function cause the debilitating symptoms of depression? Can we use
the answers to this question to invent more effective, faster acting antidepressant drug …
the answers to this question to invent more effective, faster acting antidepressant drug …
Sex shapes cell-type-specific transcriptional signatures of stress exposure in the mouse hypothalamus
Stress-related psychiatric disorders and the stress system show prominent differences
between males and females, as well as strongly divergent transcriptional changes. Despite …
between males and females, as well as strongly divergent transcriptional changes. Despite …
[HTML][HTML] Parvalbumin interneuron alterations in stress-related mood disorders: A systematic review
Stress-related psychiatric disorders including depression involve complex cellular and
molecular changes in the brain, and GABAergic signaling dysfunction is increasingly …
molecular changes in the brain, and GABAergic signaling dysfunction is increasingly …
Somatostatin and somatostatin-containing interneurons—from plasticity to pathology
Despite the obvious differences in the pathophysiology of distinct neuropsychiatric diseases
or neurodegenerative disorders, some of them share some general but pivotal mechanisms …
or neurodegenerative disorders, some of them share some general but pivotal mechanisms …
Electronically reconfigurable memristive neuron capable of operating in both excitation and inhibition modes
L Hu, Z Li, J Shao, P Cheng, J Wang, AV Vasilakos… - Nano Letters, 2024 - ACS Publications
Threshold switching (TS) memristors are promising candidates for artificial neurons in
neuromorphic systems. However, they often lack biological plausibility, typically functioning …
neuromorphic systems. However, they often lack biological plausibility, typically functioning …
Behavioral deficits induced by somatostatin-positive GABA neuron silencing are rescued by alpha 5 GABA-A receptor potentiation
Introduction Deficits in somatostatin-positive gamma-aminobutyric acid interneurons (SST+
GABA cells) are commonly reported in human studies of mood and anxiety disorder patients …
GABA cells) are commonly reported in human studies of mood and anxiety disorder patients …
Tianeptine promotes lasting antiallodynic effects in a mouse model of neuropathic pain
Tricyclic antidepressants (TCAs), such as desipramine (DMI), are effective at managing
neuropathic pain symptoms but often take several weeks to become effective and also lead …
neuropathic pain symptoms but often take several weeks to become effective and also lead …