Sepsis is characterised by a dysregulated host immune response to infection. Despite
recognition of its significance, immune status monitoring is not implemented in clinical …

For more than two decades, sepsis was defined as a microbial infection that produces fever
(or hypothermia), tachycardia, tachypnoea and blood leukocyte changes. Sepsis is now …

Dysregulation of the immune response to bacterial infection can lead to sepsis, a condition
with high mortality. Multiple whole-blood gene-expression studies have defined sepsis …

Background Host responses during sepsis are highly heterogeneous, which hampers the
identification of patients at high risk of mortality and their selection for targeted therapies. In …

Purpose Sepsis is a heterogeneous syndrome and identification of sub-phenotypes is
essential. This study used trajectories of vital signs to develop and validate sub-phenotypes …

Background Active pulmonary tuberculosis is difficult to diagnose and treatment response is
difficult to effectively monitor. A WHO consensus statement has called for new non-sputum …

Objectives: To find and validate generalizable sepsis subtypes using data-driven clustering.
Design: We used advanced informatics techniques to pool data from 14 bacterial sepsis …

Over the past two decades, the diagnosis rate for patients with encephalitis has remained
poor despite advances in pathogen-specific testing such as PCR and antigen assays …

Despite significant progress in antibiotic discovery, millions of lives are lost annually to
infections. Surprisingly, the failure of antimicrobial treatments to effectively eliminate …

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