Cancer is one of the major healthcare challenges across the globe. Several anticancer
drugs are available on the market but they either lack specificity or have poor safety, severe …

Global public health is confronted with significant challenges due to the prevalence of
cancer and the emergence of treatment resistance. This work focuses on the identification of …

Cancer prevalence and resistance issues in cancer treatment are a significant public health
concern globally. Among the existing strategies in cancer therapy, targeting cyclin …

Anaplastic thyroid carcinoma (ATC) is the most aggressive thyroid cancer, and it has a poor
prognosis and high probability of metastatic recurrence. The long-term survival of cancer …

Hepatocellular carcinoma (HCC) is a highly prevalent malignant tumor that is associated
with substantial morbidity and mortality rates. Despite the progress made in diagnostic …

This study investigates a series of newly synthesized compounds, including
pyridopyrimidine derivatives (9a-g), tricyclic pyridotriazolopyrimidine analogs (18a-d), and …

Disulfidptosis, a newly discovered type of programmed cell death, could be a mechanism of
cell death controlled by SLC7A11. This could be closely associated with tumor development …

Cancer is a major cause of deaths across the globe due to chemoresistance and lack of
selective chemotherapy. Pyrido [2, 3-d] pyrimidine is an emerging scaffold in medicinal …

The extracellular matrix (ECM) is a multifunctional network of macromolecules that regulate
various cellular functions and physically support the tissues. Besides physiological …

Cancer is the uncontrolled proliferation of abnormal cells that invade other areas, spread to
other organs, and cause metastases, which is the most common cause of death. A review of …