Calcific aortic valve disease: from molecular and cellular mechanisms to medical therapy
Calcific aortic valve disease (CAVD) is a highly prevalent condition that comprises a disease
continuum, ranging from microscopic changes to profound fibro-calcific leaflet remodelling …
continuum, ranging from microscopic changes to profound fibro-calcific leaflet remodelling …
Multi-omics approaches to define calcific aortic valve disease pathogenesis
Calcific aortic valve disease sits at the confluence of multiple world-wide epidemics of aging,
obesity, diabetes, and renal dysfunction, and its prevalence is expected to nearly triple over …
obesity, diabetes, and renal dysfunction, and its prevalence is expected to nearly triple over …
Multiomics of tissue extracellular vesicles identifies unique modulators of atherosclerosis and calcific aortic valve stenosis
BACKGROUND: Fewer than 50% of patients who develop aortic valve calcification have
concomitant atherosclerosis, implying differential pathogenesis. Although circulating …
concomitant atherosclerosis, implying differential pathogenesis. Although circulating …
Innate and adaptive immunity: the understudied driving force of heart valve disease
F Bartoli-Leonard, J Zimmer… - Cardiovascular research, 2021 - academic.oup.com
Calcific aortic valve disease (CAVD), and its clinical manifestation that is calcific aortic valve
stenosis, is the leading cause for valve disease within the developed world, with no current …
stenosis, is the leading cause for valve disease within the developed world, with no current …
Unraveling the mechanisms of valvular heart disease to identify medical therapy targets: a scientific statement from the American Heart Association
AM Small, KE Yutzey, BA Binstadt, K Voigts Key… - Circulation, 2024 - ahajournals.org
Valvular heart disease is a common cause of morbidity and mortality worldwide and has no
effective medical therapy. Severe disease is managed with valve replacement procedures …
effective medical therapy. Severe disease is managed with valve replacement procedures …
Apolipoprotein C3 induces inflammasome activation only in its delipidated form
Increased levels of apolipoprotein C3 (APOC3) in the blood predict cardiovascular disease
risk in people with and without diabetes 1–4. Conversely, APOC3 loss-of-function variants …
risk in people with and without diabetes 1–4. Conversely, APOC3 loss-of-function variants …
APOC-III: a gatekeeper in controlling triglyceride metabolism
Abstract Purpose of Review Apolipoprotein C-III (ApoC-III) is a widely known player in
triglyceride metabolism, and it has been recently recognized as a polyhedric factor which …
triglyceride metabolism, and it has been recently recognized as a polyhedric factor which …
The lipocalin apolipoprotein D functional portrait: a systematic review
Apolipoprotein D is a chordate gene early originated in the Lipocalin protein family. Among
other features, regulation of its expression in a wide variety of disease conditions in humans …
other features, regulation of its expression in a wide variety of disease conditions in humans …
[HTML][HTML] Beyond VICs: Shedding light on the overlooked VECs in calcific aortic valve disease
L Fan, D Yao, Z Fan, T Zhang, Q Shen, F Tong… - Biomedicine & …, 2024 - Elsevier
Calcific aortic valve disease (CAVD) is prevalent in developed nations and has emerged as
a pressing global public health concern due to population aging. The precise etiology of this …
a pressing global public health concern due to population aging. The precise etiology of this …
The complex relationship between hypoxia signaling, mitochondrial dysfunction and inflammation in calcific aortic valve disease: insights from the molecular …
Calcific aortic valve stenosis (CAVS) is among the most common causes of cardiovascular
mortality in an aging population worldwide. The pathomechanisms of CAVS are such a …
mortality in an aging population worldwide. The pathomechanisms of CAVS are such a …