Fc-mediated antibody effector functions during respiratory syncytial virus infection and disease
EA Van Erp, W Luytjes, G Ferwerda… - Frontiers in …, 2019 - frontiersin.org
Respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract infections
and hospitalization in infants under 1 year of age and there is currently no market-approved …
and hospitalization in infants under 1 year of age and there is currently no market-approved …
Sex differences in vaccine-induced humoral immunity
S Fischinger, CM Boudreau, AL Butler… - Seminars in …, 2019 - Springer
Vaccines are among the most impactful public health interventions, preventing millions of
new infections and deaths annually worldwide. However, emerging data suggest that …
new infections and deaths annually worldwide. However, emerging data suggest that …
Antibody responses to envelope glycoproteins in HIV-1 infection
DR Burton, JR Mascola - Nature immunology, 2015 - nature.com
Antibody responses to the HIV-1 envelope glycoproteins can be classified into three groups.
Binding but non-neutralizing responses are directed to epitopes that are expressed on …
Binding but non-neutralizing responses are directed to epitopes that are expressed on …
Engaging innate immunity in HIV-1 cure strategies
Combination antiretroviral therapy (ART) can block multiple stages of the HIV-1 life cycle to
prevent progression to AIDS in people living with HIV-1. However, owing to the persistence …
prevent progression to AIDS in people living with HIV-1. However, owing to the persistence …
Polyfunctional HIV-specific antibody responses are associated with spontaneous HIV control
Elite controllers (ECs) represent a unique model of a functional cure for HIV-1 infection as
these individuals develop HIV-specific immunity able to persistently suppress viremia …
these individuals develop HIV-specific immunity able to persistently suppress viremia …
Natural variation in Fc glycosylation of HIV-specific antibodies impacts antiviral activity
While the induction of a neutralizing antibody response against HIV remains a daunting
goal, data from both natural infection and vaccine-induced immune responses suggest that it …
goal, data from both natural infection and vaccine-induced immune responses suggest that it …
Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial target multiple epitopes and preferentially use the VH1 gene family
M Bonsignori, J Pollara, MA Moody, MD Alpert… - Journal of …, 2012 - Am Soc Microbiol
ABSTRACT The ALVAC-HIV/AIDSVAX-B/E RV144 vaccine trial showed an estimated
efficacy of 31%. RV144 secondary immune correlate analysis demonstrated that the …
efficacy of 31%. RV144 secondary immune correlate analysis demonstrated that the …
[KNJIGA][B] HIV and the pathogenesis of AIDS.
JA Levy - 1994 - cabidigitallibrary.org
This book grew out of a scientific review, originally published in Microbiological Reviews. It
has been updated and expanded-now citing more than 2100 references (100 pages of the …
has been updated and expanded-now citing more than 2100 references (100 pages of the …
Mouse model recapitulating human Fcγ receptor structural and functional diversity
The in vivo biological activities of IgG antibodies result from their bifunctional nature, in
which antigen recognition by the Fab is coupled to the effector and immunomodulatory …
which antigen recognition by the Fab is coupled to the effector and immunomodulatory …
Interaction with cellular CD4 exposes HIV-1 envelope epitopes targeted by antibody-dependent cell-mediated cytotoxicity
M Veillette, A Désormeaux, H Medjahed… - Journal of …, 2014 - Am Soc Microbiol
ABSTRACT Anti-HIV-1 envelope glycoprotein (Env) antibodies without broadly neutralizing
activity correlated with protection in the RV144 clinical trial, stimulating interest in other …
activity correlated with protection in the RV144 clinical trial, stimulating interest in other …