Cardiovascular diseases (CVD) are the leading cause of death worldwide, and advanced
age is a main contributor to the prevalence of CVD. Cellular senescence is an irreversible …

Cardiovascular disease is the leading cause of mortality and morbidity worldwide. Despite
improvements in the standard of care for patients with heart diseases, including innovation …

Myocardial infarction (MI) causes cell death, disrupts electrical activity, triggers arrhythmia,
and results in heart failure, whereby 50–60% of MI‐associated deaths manifest as sudden …

Stem cells represent an attractive resource for cardiac regeneration. However, the survival
and function of transplanted stem cells is poor and remains a major challenge for the …

Recent advances in both cardiac tissue engineering and hearts‐on‐a‐chip are grounded in
new biomaterial development as well as the employment of innovative fabrication …

Background Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) can
be used to treat heart diseases; however, the optimal maturity of hiPSC-CMs for effective …

Developmental research has attempted to untangle the exact signals that control heart
growth and size, with knockout studies in mice identifying pivotal roles for Wnt and Hippo …

Cardiac regenerative therapy using human pluripotent stem cell-derived cardiomyocytes
(hPSC-CMs) is expected to become an alternative to heart transplantation for severe heart …

Human pluripotent stem cells (hPSCs) are uniquely suited to study human development and
disease and promise to revolutionize regenerative medicine. These applications rely on …

The advent of human induced pluripotent stem cells (hiPSCs) and their capacity to be
differentiated into beating human cardiomyocytes (CMs) in vitro has revolutionized human …