Abstract Purpose of Review Multiple sclerosis (MS) is a chronic, immune-mediated
demyelinating disorder of the central nervous system. Age is one of the most important …

Mendelian randomisation (MR) is an established technique in epidemiological investigation,
using the principle of random allocation of genetic variants at conception to estimate the …

Background Telomeres form repeated DNA sequences at the ends of chromosomes, which
shorten with each cell division. Yet, factors modulating telomere attrition and the health …

Telomeres form protective caps at the ends of chromosomes, and their attrition is a marker of
biological aging. Short telomeres are associated with an increased risk of neurological and …

Background Telomere length has long been recognized as a valuable biomarker of aging
and is inversely correlated with chronological age. Various lifestyle factors have been …

Background and aims The relationship between alcohol consumption and age‐related
diseases is inconsistent. Biological age (BA) serves as both a precursor and a predictor of …

Mitochondrial DNA (mtDNA) copy number and telomere length (TL) are dynamic factors that
have been linked to the aging process in organisms. However, the causal relationship …

Women typically outlive men, yet they often experience greater frailty and a higher incidence
of chronic diseases as they age. By exploring the biological foundations of aging, with a …

Tobacco, alcohol, and marijuana consumption is an important public health problem
because of their high use worldwide and their association with the risk of mortality and many …

Background Due to the inadequacy of published evidence, association of telomere length
(TL), obesity and tobacco smoking with idiopathic pulmonary fibrosis (IPF) remains unclear …