Recent development of gold (I) and gold (III) complexes as therapeutic agents for cancer diseases

Y Lu, X Ma, X Chang, Z Liang, L Lv, M Shan… - Chemical Society …, 2022 - pubs.rsc.org
Metal complexes have demonstrated significant antitumor activities and platinum complexes
are well established in the clinical application of cancer chemotherapy. However, the …

An updated overview on nitrogen-rich azole-based gold coordination complexes as potent anticancer agents

M Ghorbanpour, B Soltani - Coordination Chemistry Reviews, 2025 - Elsevier
The ability of gold-based complexes in diagnosis and treatment of cancers as the main
worldwide health problems, along with the successful clinical reports of bioactive azole …

Heteroleptic silver (I) and gold (I) N-heterocyclic carbene complexes: structural characterization, computational analysis, tyrosinase inhibitory, and biological effects

A Neshat, A Mahdavi, MR Yousefshahi… - Inorganic …, 2023 - ACS Publications
Derivatization of (NHC) M-Cl (M= Ag, Au) with selected sulfur donors from the family of
dialkyldithiophosphates and bis (2-mercapto-1-methylimidazolyl) borate ligands gave a …

Dinuclear gold (I) complexes based on carbene and diphosphane ligands: bis [2-(dicyclohexylphosphano) ethyl] amine complex inhibits the proteasome activity …

N Casagrande, C Borghese, G Corona… - JBIC Journal of …, 2023 - Springer
Three new dinuclear gold (I) complexes (1–3) containing a carbene (1, 3-Bis (2, 6-di-
isopropylphenyl) imidazol-2-ylidene (IPr)) and diphosphane ligands [bis (1, 2 …

Design, synthesis, and preclinical activity in ovarian cancer models of new phosphanegold (I)-N-heterocyclic carbene complexes

AAA Sulaiman, N Casagrande… - Journal of Medicinal …, 2022 - ACS Publications
A new series of seven gold (I) complexes (1–7) containing 1, 3-bis (2, 6-diisopropylphenyl)
imidazol-2-ylidene (IPr) and phosphane ligands (L1–L7) were synthesized and evaluated …

Selective cytotoxicity of cyclometalated gold (III) complexes on Caco-2 cells is mediated by G2/M cell cycle arrest

E Abás, A Bellés, A Rodríguez-Diéguez, M Laguna… - Metallomics, 2021 - academic.oup.com
New cyclometalated gold (III) complexes with a general structure [Au (C^ N)(SR) 2] or [Au
(C^ N) Cl (SR)], where C^ N is a biphenyl ligand such as 2-(p-tolyl) pyridinate (tpy), 2 …

N-Heterocyclic Carbene-Au(I)-Phosphine Complexes: Characterization, Theoretical Structure Analysis, and Anti-Cancer Properties

MR Yousefshahi, M Cheraghi, T Ghasemi… - …, 2024 - ACS Publications
Derivatization of (NHC) Au–Cl with monodentate and bidentate phosphine donors, such as
PPh2Py, PPh3, PCy3, and dppf, produced heteroleptic mononuclear and binuclear Au (I) …

Cleaner, Greener Synthesis and Anticancer Screening of Asymmetrical Trithiocarbonates

N Srivastava, D Chaturvedi, R Kishore… - Organic Preparations …, 2024 - Taylor & Francis
Trithiocarbonates have important applications throughout chemistry. They are used in
agrochemicals 1–3 and lubricants. 4–6 They are significant components in polymerization …

Anti‐Tumoural [NHC (thiolato)] Gold (I) Complexes Derived from HIF‐1α Inhibitor AC1‐004 Target the Mitochondrial Redox System and Show Antiangiogenic Effects …

SW Schleser, LHF Köhler, F Riethmüller… - …, 2023 - Wiley Online Library
AC1‐004 is a potent inhibitor of the hypoxia‐inducible factor alpha (HIF‐1α) pathway,
essential for tumour growth, angiogenesis and metastasis. We modelled a series of gold (I) …

Luminescent zero-dimensional hybrid lead thiohalide nanostructures for high quantum yield and broadband excitation

NN Golovnev, AS Aleksandrovsky… - ACS Applied Nano …, 2021 - ACS Publications
Luminescent trans-[Pb (DMTU-S) 4Cl2](DMTU: N, N′-dimethylthiourea) was designed and
prepared via either mechanochemical or solvothermal methods, and the structures of DMTU …