Abstract The 3, 3′‐pyrrolidinyl‐spirooxindole unit is a privileged heterocyclic motif that
forms the core of a large family of alkaloid natural products with strong bioactivity profiles …

Throughout the ages, Nature has catered to the basic needs of humans, not the least of
which is the provision of medicines for the treatment of a wide spectrum of diseases. Plants …

Protein acetylation, especially histone acetylation, is the subject of both research and clinical
investigation. At least four small-molecule histone deacetylase inhibitors are currently in …

There is mounting urgency to find new drugs for the treatment of serious infectious diseases
and cancer that are rapidly develo** resistance to previously effective drugs. One …

Abstract Das 3, 3′‐Pyrrolidinylspirooxindol‐System ist ein privilegiertes heterocyclisches
Strukturmotiv, das die zentrale Einheit bei einer großen Familie von natürlichen Alkaloiden …

In the last few decades, the use of transition metals in organic synthesis has become
commonplace. 1 A distinct group of late transition metals, the so-called coinage metals, are …

Small molecules that alter protein function provide a means to modulate biological networks
with temporal resolution. Here we demonstrate a potentially general and scalable method of …

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We report a new catalyst system that should enhance the use of enantioselective 1, 3-
dipolar cycloadditions of azomethine ylides with electronic-deficient olefins in the divergent …

Chemical genomics involves generating large collections of small molecules and using
them to modulate cellular states. Despite recent progress in the systematic synthesis of …