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Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors
The development of new CRISPR–Cas genome editing tools continues to drive major
advances in the life sciences. Four classes of CRISPR–Cas-derived genome editing agents …
advances in the life sciences. Four classes of CRISPR–Cas-derived genome editing agents …
Genetic instabilities in human cancers
Whether and how human tumours are genetically unstable has been debated for decades.
There is now evidence that most cancers may indeed be genetically unstable, but that the …
There is now evidence that most cancers may indeed be genetically unstable, but that the …
[کتاب][B] Casarett and Doull's toxicology: the basic science of poisons
CD Klaassen, MO Amdur - 2013 - researchgate.net
The question of what constitutes an acceptable risk is a matter of judgement. Such decisions
are multifaceted and complex, and involve a balance of risk and benefit. High risks may be …
are multifaceted and complex, and involve a balance of risk and benefit. High risks may be …
Toxic effects of ultraviolet radiation on the skin
Y Matsumura, HN Ananthaswamy - Toxicology and applied pharmacology, 2004 - Elsevier
Ultraviolet (UV) irradiation present in sunlight is an environmental human carcinogen. The
toxic effects of UV from natural sunlight and therapeutic artificial lamps are a major concern …
toxic effects of UV from natural sunlight and therapeutic artificial lamps are a major concern …
Endogenous DNA damage in humans: a review of quantitative data
R De Bont, N Van Larebeke - Mutagenesis, 2004 - academic.oup.com
DNA damage plays a major role in mutagenesis, carcinogenesis and ageing. The vast
majority of mutations in human tissues are certainly of endogenous origin. A thorough …
majority of mutations in human tissues are certainly of endogenous origin. A thorough …
Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism
Replication protein A [RPA; also known as replication factor A (RFA) and human single-
stranded DNA-binding protein] is a single-stranded DNA-binding protein that is required for …
stranded DNA-binding protein] is a single-stranded DNA-binding protein that is required for …
[HTML][HTML] Metabolism and function of coenzyme Q
M Turunen, J Olsson, G Dallner - Biochimica et Biophysica Acta (BBA) …, 2004 - Elsevier
Coenzyme Q (CoQ) is present in all cells and membranes and in addition to be a member of
the mitochondrial respiratory chain it has also several other functions of great importance for …
the mitochondrial respiratory chain it has also several other functions of great importance for …
DNA damage and repair
EC Friedberg - Nature, 2003 - nature.com
The aesthetic appeal of the DNA double helix initially hindered notions of DNA mutation and
repair, which would necessarily interfere with its pristine state. But it has since been …
repair, which would necessarily interfere with its pristine state. But it has since been …
UV-induced skin damage
M Ichihashi, M Ueda, A Budiyanto, T Bito, M Oka… - Toxicology, 2003 - Elsevier
Solar radiation induces acute and chronic reactions in human and animal skin. Chronic
repeated exposures are the primary cause of benign and malignant skin tumors, including …
repeated exposures are the primary cause of benign and malignant skin tumors, including …
Cellular responses to DNA damage
Cells are constantly under threat from the cytotoxic and mutagenic effects of DNA damaging
agents. These agents can either be exogenous or formed within cells. Environmental DNA …
agents. These agents can either be exogenous or formed within cells. Environmental DNA …