Human cytomegalovirus (HCMV) establishes a latent infection that generally remains
asymptomatic in immune-competent hosts for decades but can cause serious illness in …

Tissues such as the skin and mucosae are frequently exposed to microbial pathogens.
Infectious agents must be quickly and efficiently controlled by our immune system, but the …

Diet is the only known intervention which has been conclusively shown to extend life span. It
can be argued the key role diet has to play in the aging process came to prominence as a …

Immune checkpoint blockade (ICB) of PD-1 and CTLA-4 to treat metastatic melanoma (MM)
has variable therapeutic benefit. To explore this in peripheral samples, we characterized …

A central feature of the SARS-CoV-2 pandemic is that some individuals become severely ill
or die, whereas others have only a mild disease course or are asymptomatic. Here, we …

A cytomegalovirus (CMV) vaccine that is effective at preventing congenital infection and
reducing CMV disease in transplant patients remains a high priority as no approved …

An age‐related decline in immune functions, referred to as immunosenescence, is partially
responsible for the increased prevalence and severity of infectious diseases, and the low …

Human cytomegalovirus (HCMV) infections of immunocompetent hosts are characterized by
a dynamic, life-long interaction in which host immune responses, particularly of T cells …

Background: Coronary artery disease is an incurable, life-threatening disease that was once
considered primarily a disorder of lipid deposition. Coronary artery disease is now also …

Human cytomegalovirus (CMV) is a betaherpesvirus in the same family as human
herpesvirus-6 and-7. CMV is a large virus including approximately 200 proteins. CMV has …