Abstract Methylation of Lys and Arg residues on non-histone proteins has emerged as a
prevalent post-translational modification and as an important regulator of cellular signal …

Epigenetics governs a chromatin state regulatory system through five key mechanisms: DNA
modification, histone modification, RNA modification, chromatin remodeling, and non-coding …

When B cells encounter an antigen, they alter their physiological state and anatomical
localization and initiate a differentiation process that ultimately produces antibody-secreting …

Maintenance of genome integrity and stability is a critical responsibility of the DNA damage
response (DDR) within cells, such that any disruption in this kinase-based signaling …

Methylation of histone H3 lysine 36 (H3K36) plays crucial roles in the partitioning of
chromatin to distinctive domains and the regulation of a wide range of biological processes …

Epigenetic processes are essential for normal development and the maintenance of tissue-
specific gene expression in mammals. Changes in gene expression and malignant cellular …

SETDB1 (SET domain bifurcated histone lysine methyltransferase 1) is a protein lysine
methyltransferase and methylates histone H3 at lysine 9 (H3K9). Among other H3K9 …

Genomic integrity of the cell is crucial for the successful transmission of genetic information
to the offspring and its survival. Persistent DNA damage induced by endogenous and …

Most molecular processes during plant development occur with a particular spatio-temporal
specificity. Thus far, it has remained technically challenging to capture dynamic protein …

PRMT5 is an arginine methyltransferase that accounts for the vast majority of the symmetric
methylation in cells. PRMT5 exerts its function when complexed with MEP50/WDR77. This …