Neurofibrillary tangles, one of the neuropathologic hallmarks of Alzheimer's disease, have a
dynamic lifespan of maturity that associates with progressive neuronal dysfunction and …

The neuropathological hallmarks of Alzheimer disease (AD) include “positive” lesions such
as amyloid plaques and cerebral amyloid angiopathy, neurofibrillary tangles, and glial …

Alzheimer's disease is the most common neurodegenerative disease, and there are no
mechanism-based therapies. The disease is defined by the presence of abundant …

The transition between soluble intrinsically disordered tau protein and aggregated tau in
neurofibrillary tangles in Alzheimer's disease is unknown. Here, we propose that soluble tau …

We developed stable isotope labeling and mass spectrometry approaches to measure the
kinetics of multiple isoforms and fragments of tau in the human central nervous system …

Formation of membrane-less organelles via liquid-liquid phase separation is one way cells
meet the biological requirement for spatiotemporal regulation of cellular components and …

Alzheimer's disease is the most common neurodegenerative disorder that can cause
dementia in elderly over 60 years of age. One of the disease hallmarks is oxidative stress …

Neurofibrillary tangles (NFTs) are a pathological hallmark of Alzheimer's disease (AD);
however, the relationship between NFTs and disease progression remains controversial …

The lesions of Alzheimer disease include accumulation of proteins, losses of neurons and
synapses, and alterations related to reactive processes. Extracellular Aβ accumulation …

Mutations in the amyloid precursor protein (APP) gene cause early-onset familial Alzheimer
disease (AD) by affecting the formation of the amyloid β (Aβ) peptide, the major constituent …